Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
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DOI：
10.1016/j.devcel.2014.10.022
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发表时间：
2014-12-01
影响因子：
11.8
通讯作者：
Biernaskie, Jeff
中科院分区：
文献类型：
--
作者：
Rahmani, Waleed;Abbasi, Sepideh;Biernaskie, Jeff
毛乳头（DP）提供激活上皮祖细胞和启动毛囊再生所需的指导性信号。DP细胞数量在毛发周期中波动，脱发与DP细胞的逐渐消耗/萎缩相关。DP细胞数量如何维持在健康卵泡中仍不清楚。我们进行了体内的成年毛囊真皮鞘（DS）细胞的命运映射，以确定其与DP的谱系关系，并发现DS细胞的一个子集保留每个毛发周期后，表现出自我更新，并重新填充DS和DP与新的细胞。扩增这些毛囊真皮干细胞及其后代延缓了毛发再生并改变了毛发类型，表明它们具有调节正常DP功能的功能。这项工作确定了成人毛囊间充质中的双能干细胞，并对损伤，疾病和衰老后头发生长的恢复具有重要意义。
The dermal papilla (DP) provide instructive signals required to activate epithelial progenitors and initiate hair follicle regeneration. DP cell numbers fluctuate over the hair cycle, and hair loss is associated with gradual depletion/atrophy of DP cells. How DP cell numbers are maintained in healthy follicles remains unclear. We performed in vivo fate mapping of adult hair follicle dermal sheath (DS) cells to determine their lineage relationship with DP and found that a subset of DS cells are retained following each hair cycle, exhibit self-renewal, and repopulate the DS and the DP with new cells. Ablating these hair follicle dermal stem cells and their progeny retarded hair regrowth and altered hair type specification, suggesting that they function to modulate normal DP function. This work identifies a bipotent stem cell within the adult hair follicle mesenchyme and has important implications toward restoration of hair growth after injury, disease, and aging.