Four New Insect Antifeedant neo-Clerodane Diterpenoids, Ajugacumbins A, B, C and D, from Ajuga decumbens
Four New Insect Antifeedant neo-Clerodane Diterpenoids, Ajugacumbins A, B, C and D, from Ajuga decumbens
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DOI：
10.1248/cpb.37.2505
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发表时间：
1989-09
影响因子：
1.7
通讯作者：
Z. Min;Shi-qiang Wang;Q. Zheng;Binrg Wu;M. Mizuno;Toŝhiyuki Tanaka;M. Iinuma
中科院分区：
文献类型：
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作者：
Z. Min;Shi-qiang Wang;Q. Zheng;Binrg Wu;M. Mizuno;Toŝhiyuki Tanaka;M. Iinuma
从虎杖全草的乙醇提取物中分离得到4个新的新核桃烷二萜类化合物，分别命名为竹节花苷A、B、C和D(1-4)。经X-射线衍射分析确定其构型为6-α-乙酰氧基-4，17-环氧基-18-硫氧基-新核酮-13-烯-15，16-内酯。经波谱分析鉴定为4，17-epoxy-6α-hydroxy-18-tigloyloxy-neo-cleroda-13-en-15，16-内酯(2)，1-17-epoxy-3β-hydroxy-18-tigloyloxy-neo-cleroda-13-en-15，，3-α，6-β-6-α-三乙酰氧基-4，17-环氧基-18-新环氧基-13-烯-15，16-内酯(3)和6-α-乙酰氧基-4，16-内酯(4)。这些化合物具有一定的拒食活性。
From the ethanol extract of whole herbs of Ajuga decumbens (Labiatae), four new neo-clerodane diterpenoids, named ajugacumbins A, B, C and D (1-4), were isolated. The configuration of 1 was determined to be 6α-acetoxy-4, 17-epoxy-18-tigloyloxy-neo-cleroda-13-en-15, 16-olide by X-ray analysis. THe other structures were also determined by spectroscopic analysis to be 4, 17-epoxy-6α-hydroxy-18-tigloyloxy-neo-cleroda-13-en-15, 16-olide (2), 1α, 3β, 6α-triacetoxy-4, 17-epoxy-18-tigloyloxy-neo-cleroda-13-en-15, 16-olide (3) and 6α-acetoxy-4, 17-epoxy-3β-hydroxy-18-tigloyloxy-neo-cleroda-13-en-15, 16-olide (4). These compounds displayed insect antifeedant activity.