Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus.
Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus.
复制标题
DOI：
10.1016/j.physbeh.2009.02.018
复制
发表时间：
2009-05-25
影响因子：
2.9
通讯作者：
Heesch, Cheryl M.
中科院分区：
文献类型：
--
作者：
Kvochina, Lyudmyla;Hasser, Eileen M.;Heesch, Cheryl M.
关键词：
与非妊娠（NP）动物相比，妊娠（P）动物对血管紧张素II 1型（AT 1）受体拮抗剂（AT 1X）外周或中枢输注的降压反应更大。雄性大鼠室旁核（PVN）AT 1和离子型兴奋性氨基酸（EAA）受体参与了荷包牡丹碱（Bic）阻断GABA AA受体的升压反应。因此，我们假设GABA能抑制减少，AT 1受体在P大鼠PVN中发挥更大的兴奋作用。在PVN中在AT 1X阻断之前（Bic 1）、之后（Bic 2）和AT 1X + EAA阻断之后（犬尿氨酸盐，Kyn）（Bic 3）进行单侧微量注射Bic。在P大鼠中，Bic（Bic 1）引起的平均动脉压（MAP：NP= 20 ± 2; P= 12 ± 2 mmHg）、心率（HR：NP= 57 ± 6; P= 19 ± 6次/min）和肾交感神经活动（RSNA：NP= 70 ± 9; P= 33 ± 7%）的增加减弱。两组对AT 1X和Kyn单独治疗的反应均不显著。在NP大鼠中，AT 1X减弱（+12 ± 4 mmHg），AT 1X + Kyn进一步降低PVN中对Bic的升压反应（+6 ± 2 mmHg）。在P大鼠中，AT 1X降低了对Bic的升压反应（+5 ± 1 mmHg），Kyn没有额外的作用（+3 ± 1 mmHg）。在两组中，PVN Bic改变RSNA自身谱的作用被先前的AT 1X和Kyn抑制。因此，紧张性GABA能抑制减少，AT 1受体在PVN的贡献可能是更大的P大鼠。
Depressor responses to peripheral or central infusion of Angiotensin II type 1 (AT1) receptor antagonists (AT1X) are greater in pregnant (P) compared to nonpregnant (NP) animals. AT1 and ionotropic excitatory amino acid (EAA) receptors contribute to pressor responses to GABAA receptor blockade with bicuculline (Bic) in the paraventricular nucleus (PVN) of male rats. Therefore, we hypothesized that GABAergic inhibition is decreased and AT1 receptors play a greater excitatory role in the PVN of P versus NP rats. Unilateral microinjection of Bic was performed before (Bic1), after AT1X (Bic2), and after AT1X + EAA blockade (kynurenate, Kyn) (Bic3) in the PVN. Increases in mean arterial pressure (MAP: NP= 20 ± 2; P= 12 ± 2 mmHg), heart rate (HR: NP= 57 ± 6; P= 19 ± 6 beats/min) and renal sympathetic nerve activity (RSNA: NP= 70 ± 9; P= 33 ± 7 %) due to Bic (Bic1) were attenuated in P rats. Responses to AT1X and Kyn alone were insignificant in both groups. In NP rats, AT1X attenuated (+12 ± 4 mmHg), and AT1X + Kyn further decreased the pressor response to Bic in the PVN (+6 ± 2 mmHg). In P rats AT1X reduced the pressor response to Bic (+5 ± 1 mm Hg), and Kyn had no additional effect (+3 ± 1 mmHg). Effects of PVN Bic to alter the autospectra of RSNA were suppressed by prior AT1X and Kyn in both groups. Thus, tonic GABAergic inhibition is decreased and the contribution of AT1 receptors in the PVN may be greater in P rats.
登录
查看更多内容
影响因子：
4
作者：
GARLAND, HO;ATHERTON, JC;MILNE, CM
通讯作者：
MILNE, CM
影响因子：
4.8
作者：
BRIDGES, RS
通讯作者：
BRIDGES, RS
DOI：
10.1152/ajpheart.00673.2002
发表时间：
2003-05-01
影响因子：
4.8
作者：
Kenney, MJ;Weiss, ML;Fels, RJ
通讯作者：
Fels, RJ
影响因子：
5.5
作者：
Ericsson, Anette;Saljo, Karin;Jansson, Thomas
通讯作者：
Jansson, Thomas
影响因子：
2.5
作者：
Cato, MJ;Toney, GM
通讯作者：
Toney, GM