Angio-oedema and urticaria associated with angiotensin converting enzyme inhibitors.
Angio-oedema and urticaria associated with angiotensin converting enzyme inhibitors.
复制标题
与血管紧张素转换酶抑制剂相关的血管性水肿和荨麻疹。
DOI：
10.1136/bmj.294.6564.91
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Rawlins
中科院分区：
文献类型：
--
作者：
S. Wood;R. Mann;M. Rawlins
对药品安全委员会从其首次销售之日（分别为1981年5月和1985年1月）至1986年1月收到的来自英国的关于卡托普利和依那普利疑似不良反应的所有报告进行了检查。依那普利-13例患者发生血管性水肿（表）; 1例还发生荨麻疹。6名患者在首次给药后发生反应，其余患者在5天内发生反应。没有正式的再激发试验的描述，虽然反应发生后，每两个剂量的一名患者采取了急性。12例患者在停药后1 - 2天内血管性水肿消退; 2例患者接受类固醇治疗。7名患者（4名男性）在每日剂量5-20 mg后仅报告了荨麻疹，年龄为46-80岁（平均59岁）。4例患者患有高血压，3例患有心力衰竭，同时接受利尿剂治疗。1例患者在首次给药后发生反应，3例在4天内发生，其余患者在10、14和16天内发生。停药导致所有患者的体征在1至7天内消退。卡托普利-6例患者发生血管性水肿（表）; 3例还发生荨麻疹。该反应发生在治疗开始后2至28天，4例患者在停药后1至4天内消退。另外两名患者的结局未知。17名患者（14名女性）仅报告荨麻疹，年龄53-78岁（平均64岁）。15人正在接受高血压治疗，2人正在接受心力衰竭治疗，每日剂量为25-150毫克。1例患者在首次给药后1小时发生反应，2例患者在3天后发生反应，其余患者在8-60天（平均31天）后发生反应。16名患者的体征在停药后6天内消退，但另外2名患者在停药后持续2至4周。2例患者报告了再激发阳性结果。评论
All reports from the United Kingdom of suspected adverse reactions to captopril and enalapril received by the Committee on Safety of Medicines from the dates they were first sold (May 1981 and January 1985, respectively) up to January 1986 were examined. Enalapril-Thirteen patients developed angio-oedema (table); one also developed urticaria. The reaction occurred after the first dose in six patients and within five days in the remainder. No formal rechallenge tests were described though the reaction occurred acutely after each oftwo doses taken by one patient. Angio-oedema resolved within one to two days after the drug was stopped in 12 patients; two patients were treated with steroids. Urticaria alone was reported in seven patients (four men) aged 46-80 (mean 59) after daily doses of 5-20 mg. Four patients had hypertension, and three with heart failure received concomitant diuretic treatment. The reaction occurred after the first dose in one patient, within four days in three, and within 10, 14, and 16 days in the remainder. Drug withdrawal resulted in the resolution of signs in all patients within one to seven days. Captopril-Six patients developed angio-oedema (table); three also developed urticaria. The reaction occurred two to 28 days after treatment started and resolved within one to four days after drug withdrawal in four patients. The outcome in the two other patients was unknown. Urticaria alone was reported in 17 patients (14 women) aged 53-78 (mean 64). Fifteen were being treated for hypertension and two for heart failure, with daily doses of 25-150 mg. The reaction occurred one hour after the first dose in one, after three days in two, and after 8-60 (mean 31) days in the remaining patients. The signs resolved within six days after drug withdrawal in 16 patients but persisted for two to four weeks after treatment was stopped in two others. A positive result ofrechallenge was reported for two patients. Comment