Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample
Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample
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DOI：
10.1007/s10519-005-9009-8
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Hesselbrock, V
中科院分区：
文献类型：
--
作者：
Dick, DM;Aliev, F;Hesselbrock, V
通过标准化心理测试测量的智力已被证明具有高度遗传性，尽管事实证明识别影响一般智力的特定基因很困难。我们进行了全基因组连锁分析，以确定包含影响智力的基因的染色体区域，通过 WAIS 全面智商 (FSIQ)、表现智商 (PIQ) 和语言智商 (VIQ) 进行测量。使用 Merlin 回归软件进行非参数多点连锁分析，使用来自 201 个家庭的 1111 名基因型和表型个体样本，作为酒精中毒遗传学合作研究 (COGA) 的一部分进行确定。最强的连锁证据是在靠近标记 D6S1006 的 6 号染色体上的 FSIQ（LOD=3.28，12 cM）上获得的。最近发表的澳大利亚和荷兰双胞胎智商基因组筛查中也表明该区域与暗示性连锁有关，并且与发育性阅读障碍的连锁研究有关。我们的研究结果进一步支持 6p 染色体含有影响智力的基因。
Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD=3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.