A genealogical assessment of heritable predisposition to aneurysms
A genealogical assessment of heritable predisposition to aneurysms
复制标题
DOI：
10.3171/jns.2003.99.4.0637
复制
发表时间：
2003-10-01
影响因子：
4.1
通讯作者：
Rowe, KG
中科院分区：
文献类型：
--
作者：
Albright, LAC;Camp, NJ;Rowe, KG
物体。本研究旨在调查家族和遗传因素对颅内、腹主动脉和所有其他类型动脉瘤的影响，并确定不同类型动脉瘤患者的家族关系。作者利用犹他州独有的资源对动脉瘤的家族性进行了基于人群的分析。犹他州人口数据库是犹他州人口的家谱，可以追溯到八代人，它与1904年以来犹他州的死亡证明数据结合在一起。考虑到所有来自这一来源的动脉瘤病例之间的遗传关系，作者使用了以前发表的一种方法来估计不同动脉瘤类型的熟悉度。使用从数据库中计算的内部、出生队列特定的疾病发生率，他们通过比较在确定的亲属组中观察到的和预期的动脉瘤发病率来估计相对风险。所调查的三种动脉瘤类型中的每一种都显示出遗传成分的重要证据。颅内动脉瘤患者的亲属似乎没有增加腹部或其他病变的风险，但腹主动脉瘤患者的亲属似乎有更高的风险患其他类型的这些病变。
Object. This study was conducted to investigate the familial and genetic contribution to intracranial, abdominal aortic, and all other types of aneurysms, and to define familial relationships among patients who present with the different aneurysm types.Methods. The authors used a unique Utah resource to perform population-based analysis of the familial nature of aneurysms. The Utah Population Data Base is a genealogy of the Utah population dating back eight generations, which is combined with death certificate data for the state of Utah dating back to 1904. Taking into account the genetic relationships among all aneurysm cases derived from this resource, the authors used a previously published method to estimate the familiality of different aneurysm types. Using internal, birth-cohort-specific rates of disease calculated from the database, they estimated relative risks by comparing observed to expected rates of aneurysm incidence in defined sets of relatives of probands.Conclusions. Each of the three aneurysm types investigated showed significant evidence for a genetic component. Relatives of patients with intracranial aneurysms do not appear to be at increased risk for abdominal or other lesions, but relatives of patients with abdominal aortic aneurysms appear to be at increased risk for other types of these lesions.