Auditory sensory gating in patients with bipolar disorders: A meta-analysis
Auditory sensory gating in patients with bipolar disorders: A meta-analysis
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DOI：
10.1016/j.jad.2016.06.010
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发表时间：
2016-10-01
影响因子：
6.6
通讯作者：
Hsu, Shih-Chieh
中科院分区：
文献类型：
--
作者：
Cheng, Chia-Hsiung;Chan, Pei-Ying S.;Hsu, Shih-Chieh
背景：感觉门控(Sensory Gating，SG)是指神经对第二个相同刺激的反应减弱，被概念化为抑制冗余信息的自动过程。尽管它在精神分裂症中的缺陷已经有了很好的记录，但SG受到双相情感障碍(BD)调节的程度仍然难以捉摸。因此，本研究旨在探讨BD患者SG能力的集合效应大小。方法：本研究包括10项研究，包括699名健康对照和568名BD患者，共14项独立调查。根据S_2/S_1比值和S_1-S_2差分别估计效应大小，以Cohen‘s d计算。结果：有精神病史的BD患者(d=0.847，p<；0.001)与无精神病史的BD患者(d=0.589，p<；0.001)相比，SG能力受损。此外，在群体水平上，S_1-S_2差值和S_2/S_1比值都可以区分BD患者和健康对照组。局限性：我们不能将BD患者分成不同的亚型，因此我们的数据应该谨慎地解释。结论：这些发现表明BD本身损害了SG的能力，这种能力随着精神病史的恶化而恶化。目前的认识促使进一步的研究来确定SG在BD亚型中的作用。(C)2016爱思唯尔B.V.保留所有权利。
Background: Sensory gating (SG) refers to the attenuation of neural response to the second identical stimulus and is conceptualized as an automatic process to inhibit redundant information. Although its deficit in schizophrenia has been well-documented, the degree to which SG is modulated by bipolar disorders (BD) remains elusive. Thus, the present meta-analysis study aimed to explore the pooled effect sizes of SG ability in BD patients.Methods: Ten studies consisting of 14 individual investigations were included, consisting of 699 healthy controls and 568 BD patients. The effect sizes, calculated as Cohen's d, were estimated individually for S2/S1 ratio and S1-S2 difference. Additionally, S2/S1 ratio was examined in two conditions: BD with and without a history of psychosis.Results: We found that BD patients with (d=0.847, p < 0.001) or without (d=0.589, p < 0.001) a psychotic history exhibited an impaired SG ability compared to the healthy controls. Furthermore, both S1-S2 difference score and S2/S1 ratio, at a group level, can differentiate BD patients from healthy controls. Limitations: We were not able to divide patients with BD into different subtypes, and thus our data should be interpreted with cautions.Conclusion: These findings suggest BD itself impairs SG ability, which worsens with a psychotic history. The current understanding invites future research to ascertain the role of SG in subtypes of BD. (C) 2016 Elsevier B.V. All rights reserved.