The Relative Significance of Prognostic Factors in Breast Carcinoma
The Relative Significance of Prognostic Factors in Breast Carcinoma
复制标题
乳腺癌预后因素的相对意义
DOI：
--
复制
发表时间：
1971
影响因子：
8.8
通讯作者：
M. Staunton
中科院分区：
文献类型：
--
作者：
M. Alderson;I. Hamlin;M. Staunton
Hamlin（1968）发表了一项对272例乳腺癌根治术的回顾性详细研究。对258例患者的21个预后因素的数据进行了多元回归分析，以确定每个因素的独立作用和相对重要性。研究结果证实了以前的单因素分析，并表明，9个因素是独立相关的生存。在此分析中获得的信息的数学处理允许的风险评分分配给每个病人。在该系列中发现，通过预测评分对患者进行分级与相同患者的临床分期相比与生存率更密切相关。
A retrospective detailed study of 272 cases of breast carcinoma treated by radical mastectomy was published by Hamlin (1968). An extended analysis of the material for 258 of these cases is now reported.Data for 21 prognostic factors from 258 patients have been subjected to multiple regression analysis to determine the independent effect and thus the relative importance of each factor. The findings confirm previous single factor analyses and demonstrate that nine of the factors are independently associated with survival.Mathematical manipulation of the information obtained in this analysis allowed a risk score to be allotted to each patient. Grouping of patients by the prediction scores is found in this series to be more closely related to survival than is clinical staging of the same patients.