Stimulation of renal interstitial bradykinin by sodium depletion.
Stimulation of renal interstitial bradykinin by sodium depletion.
复制标题
钠消耗刺激肾间质缓激肽。
DOI：
10.1093/ajh/6.10.863
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发表时间：
1993
影响因子：
3.2
通讯作者：
Margolius,HS
中科院分区：
文献类型：
--
作者：
Siragy,HM;Jaffa,AA;Margolius,HS
原位测量和检测肾缓激肽变化的能力将允许研究高血压或糖尿病疾病中局部激肽产生与肾功能之间的关系。一种新的肾间质微透析技术允许在正常钠饮食（50 mEq/天）的清醒狗（n = 5）中放置微透析探针 2 周后收集肾囊下间质液，并在随后的 5 天内收集低钠摄入量（10 mEq/天）。尽管在正常钠摄入期间通过放射免疫分析 (RIA) 测量的间质缓激肽无法检测到 (<0.08 pg/min)，但在低钠摄入 1 天后可以检测到 (0.34 ± 0.02 pg/min)。随后 5 天低钠摄入结束时的激肽水平为 1.94 ± 0.09 皮克/分钟 (P< .01)。数据表明肾间质激肽可以原位测量。此外，低钠饮食可以迅速增加清醒狗的间质激肽。美国高血压杂志 1993；6：863-866
The ability to measure and detect change in renal bradykinin in situ would allow study of relations between local kinin production and renal function in hypertensive or diabetic disorders. A new renal interstitial microdialysis technique allowed collections of renal subcapsular interstitial fluid 2 weeks after microdialysis probe placement in conscious dogs (n = 5) on a normal sodium diet (50 mEq/day) and for 5 subsequent days on low sodium intake (10 mEq/day). Although interstitial bradykinin measured by radioimmunoassay (RIA) was undetectable (<0.08 pg/min) during normal sodium intake, it was detectable (0.34 ± 0.02 pg/min) after 1 day of low sodium. The kinin level at the end of the 5 subsequent days on low sodium was 1.94 ± 0.09 pg/min (P< .01). The data show that renal interstitial kinin can be measured in situ. Further, a low sodium diet can rapidly increase interstitial kinin in the conscious dog. Am J Hypertens 1993;6:863-866