BEHAVIORAL PROTECTION BY MODERATE HYPOTHERMIA INITIATED AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY
BEHAVIORAL PROTECTION BY MODERATE HYPOTHERMIA INITIATED AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY
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DOI：
10.1089/neu.1993.10.57
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发表时间：
1993-03-01
影响因子：
4.2
通讯作者：
LIU, S
中科院分区：
文献类型：
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作者：
LYETH, BG;JIANG, JY;LIU, S
研究了伤后低温对中度液体撞击创伤性脑损伤 (TBI) 后行为结果的影响。在实验1中，检查了三组大鼠。第一组为常温（37.5 摄氏度）；第二组和第三组分别在受伤后 15 分钟和 30 分钟开始低温治疗（30 摄氏度）。通过腹侧冰袋实现全身冷却。 25 分钟内将大脑冷却至 30 摄氏度，并维持 60 分钟。通过颞肌中的探针间接测量脑温度。通过 TBI 后 5 天每天测量的平衡木表现、平衡木行走表现和体重减轻来评估行为结果。 TBI 后第 1 天到第 5 天，正常体温组和受伤后 30 分钟低温组均表现出显着的平衡木平衡和平衡木行走缺陷（p < 0.05）。相比之下，伤后 15 分钟低温组仅在 TBI 后第 1 天表现出显着 (p < 0.05) 平衡木行走缺陷，并在 TBI 后第 1、3 和 4 天表现出显着 (p < 0.05) 平衡木平衡缺陷。在实验 II 中，将接受 TBI 的正常体温（37.5 摄氏度）和低温（30 摄氏度）大鼠的皮质下脑温度与颞肌温度进行了比较。两组大脑温度与颞肌温度的误差均在 0.4 摄氏度以内。这些结果与 TBI 后兴奋性受体拮抗剂研究相似，表明大鼠中度液体冲击 TBI 后中度低温的治疗窗小于 30 分钟。
The effects of postinjury hypothermia on behavioral outcome following moderate fluid percussion traumatic brain injury (TBI) were examined. In Experiment 1, three groups of rats were examined. The first group was normothermic (37.5-degrees-C); and hypothermia (30-degrees-C) was initiated 15 min and 30 min postinjury in the second and third groups, respectively. Whole body cooling was achieved by ventral ice pack. Cooling of the brain to 30-degrees-C was achieved in 25 min and maintained for 60 min. Brain temperature was measured indirectly by a probe in the temporalis muscle. Behavioral outcome was assessed by beam-balance performance, beam-walking performance, and body weight loss measured daily for 5 days after TBI. Both the normothermic group and the 30-min postinjury hypothermic group exhibited significant (p < 0.05) beam-balance and beam-walking deficits on days 1 through 5 after TBI. In contrast, the 15-min postinjury hypothermic group exhibited significant (p < 0.05) beam-walking deficits only on day 1 after TBI and significant (p < 0.05) beam-balance deficits on days 1, 3, and 4 after TBI. In Experiment II, subcortical brain temperature was compared to temporalis muscle temperature in normothermic (37.5-degrees-C) and hypothermic (30-degrees-C) rats subjected to TBI. In both groups brain temperature tracked within 0.4-degrees-C of temporalis muscle temperature. These results are similar to post-TBI excitatory receptor antagonist studies and indicate a therapeutic window for moderate hypothermia of less than 30 min after moderate fluid percussion TBI in the rat.