Association between carotid haemodynamics and inflammation in patients with essential hypertension
Association between carotid haemodynamics and inflammation in patients with essential hypertension
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DOI：
10.1038/sj.jhh.1001898
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发表时间：
2005-10-01
影响因子：
2.7
通讯作者：
Higaki, J
中科院分区：
文献类型：
--
作者：
Manabe, S;Okura, T;Higaki, J
先前的研究表明，高血压会导致慢性炎症。据报道，高血压患者有高循环水平的促炎细胞因子，如白细胞介素-6 （IL-6）和高敏c反应蛋白（hs-CRP）。脉搏指数（PI）和阻力指数（RI）作为外周血管阻力的标志。在本研究中，我们评估了颈动脉血流动力学与促炎细胞因子、IL-6和hs-CRP的关系。共有41例原发性高血压患者参与。采用超声多普勒血流法测量颈总动脉内膜-中膜厚度（IMT）、收缩峰值速度（pv）、舒张峰值速度（pVd）和平均流速（mV），计算PI [(pv - pVd)/mV]和RI [(pv - pVd)/ pv]。采用酶联免疫吸附法测定血清IL-6和hs-CRP浓度。IMT与年龄、脉压呈正相关。PI、RI与脉压、IL-6、hs-CRP呈正相关。多元回归分析显示PI和RI与hs-CRP独立相关。这些结果表明，颈动脉血流动力学参数如PI和RI与高血压患者动脉粥样硬化和炎症有关。
Previous studies have shown that high blood pressure causes chronic inflammation. Hypertensive patients are reported to have high-circulating levels of proinflammatory cytokines such as interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP). The pulsatility index ( PI) and resistive index ( RI) are used as markers of peripheral vascular resistance. In the present study, we evaluated the relationship between carotid haemodynamics and the proinflammatory cytokines, IL-6 and hs-CRP. In all, 41 patients with essential hypertension participated. The intima-media thickness (IMT), peak systolic velocity (pVs), peak diastolic velocity (pVd) and mean velocity (mV) in the common carotid artery were measured using ultrasound Doppler flow methods, and PI [(pVs - pVd)/mV] and RI [(pVs - pVd)/ pVs] were calculated. Serum IL-6 and hs-CRP concentrations were measured by an enzyme-linked immunosorbent assay. IMT was positively correlated with age and pulse pressure. Both PI and RI were positively correlated with pulse pressure, IL-6 and hs-CRP. A multiple regression analysis revealed that PI and RI were independently associated with hs-CRP. These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients.