Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina
Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina
复制标题
DOI：
10.1093/ije/27.4.561
复制
发表时间：
1998-08-01
影响因子：
7.7
通讯作者：
Smith, AH
中科院分区：
文献类型：
--
作者：
Hopenhayn-Rich, C;Biggs, ML;Smith, AH
台湾的研究发现，从饮用水中摄取砷与皮肤癌、膀胱癌、肺癌、肾癌和肝癌之间存在剂量反应关系。为了调查这些协会在另一个人群中，我们进行了一项研究，在科尔多瓦，阿根廷，它有一个良好的记录的历史，砷暴露于饮用水。方法死亡率从肺，肾，肝和皮肤癌在1986-1991年期间在科尔多瓦的26个县进行了调查，扩大了作者以前的分析膀胱癌在该省。根据现有数据，将各县先验地分为低、中和高砷暴露类别。结果砷暴露对肾癌和肺癌死亡率的影响呈上升趋势，男性和女性的SMR分别为：肾癌0.87，1.33，1.57和1.00，1.36，1.81;肺癌，0.92，1.54，1.77和1.24，1.34，2.16（在所有情况下，趋势检验中P = 0.001），与先前报道的膀胱癌结果相似（男性0.80，1.28，2.14，女性1.22，1.39，1.81）。肝癌有一个小的积极趋势，但死亡率在所有三个接触组都有所增加。皮肤癌的死亡率升高，只有在高暴露组的妇女，而男性表现出令人费解的死亡率在低暴露group.Conclusions增加的证据表明，砷摄入增加肺癌和肾癌的风险。在这项研究中，砷与肝癌和皮肤癌死亡率之间的关系也不清楚。
Background Studies in Taiwan have found dose-response relations between arsenic ingestion from drinking water and cancers of the skin, bladder, lung, kidney and liver. To investigate these associations in another population, we conducted a study in Cordoba, Argentina, which has a well-documented history of arsenic exposure from drinking water.Methods Mortality from lung, kidney, liver and skin cancers during the period 1986-1991 in Cordoba's 26 counties was investigated, expanding the authors' previous analysis of bladder cancer in the province. Counties were grouped a priori into low, medium and high arsenic exposure categories based on available data. Standardized mortality ratios (SMR) were calculated using all of Argentina as the reference population.Results We found increasing trends for kidney and lung cancer mortality with arsenic exposure, with the following SMR, for men and women respectively: kidney cancer, 0.87, 1.33, 1.57 and 1.00, 1.36, 1.81; lung cancer, 0.92, 1.54, 1.77 and 1.24, 1.34, 2.16 (in all cases, P = 0.001 in trend test), similar to the previously reported bladder cancer results (0.80, 1.28, 2.14 for men, 1.22, 1.39, 1.81 for women). There was a small positive trend for liver cancer but mortality was increased in all three exposure groups. Skin cancer mortality was elevated for women only in the high exposure group, while men showed a puzzling increase in mortality in the low exposure group.Conclusions The results add to the evidence that arsenic ingestion increases the risk of lung and kidney cancers. In this study, the association between arsenic and mortality from liver and skin cancers was nor clear.