Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat.
Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat.
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室旁核和视上核在猫中枢心血管调节中的作用。
DOI：
10.1152/ajpregu.1980.239.1.r137
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
F. Calaresu
中科院分区：
文献类型：
--
作者：
J. Ciriello;F. Calaresu
为探讨室旁核（PAH）和视上核（SON）在心血管系统调节中的作用，在26只猫上进行了实验。对PAH和SON区域中组织学证实的部位的电刺激引起双侧迷走神经切断动物的动脉压增加以及脊髓（C2）动物和双侧迷走神经切断动物的心率增加。此外，刺激PAH或SON可抑制刺激颈动脉窦神经（CSN）引起的迷走反射性心动过缓并且这些区域的双侧损伤增加了反应的幅度。另一方面，这些下丘脑区域的刺激和病变并没有改变对主动脉降压神经刺激的心血管反应的幅度。这些结果表明，PAH和SON的刺激引起心血管反应，由于副交感神经和交感神经系统的活动的相互变化，这些结构保持紧张性抑制的影响，对CSN反射的心率分量。
To investigate the role of the paraventricular (PAH) and supraoptic (SON) nuclei in regulation of the cardiovascular system experiments were done in 26 cats anesthetized with alpha-chloralose, paralyzed, and artificially ventilated. Electrical stimulation of histologically verified sites in the region of the PAH and SON elicited increases in arterial pressure in bilaterally vagotomized animals and increases in heart rate both in spinal (C2) animals and in animals bilaterally vagotomized, In addition, stimulation of either the PAH or SON inhibited the reflex vagal bradycardia elicited by stimulation of the carotid sinus nerve (CSN) and bilateral lesions of these areas increased the magnitude of the response. On the other hand, stimulation and lesions of these hypothalamic regions did not alter the magnitude of the cardiovascular responses to stimulation of the aortic depressor nerve. These results demonstrate that stimulation of the PAH and SON elicit cardiovascular responses due to reciprocal changes in activity of the parasympathetic and sympathetic nervous systems and that these structures maintain a tonic inhibitory influence on the heart rate component of the CSN reflex.