Genetic Determinants of the Gut Microbiome in UK Twins.
Genetic Determinants of the Gut Microbiome in UK Twins.
复制标题
DOI：
10.1016/j.chom.2016.04.017
复制
发表时间：
2016-05-11
影响因子：
30.3
通讯作者：
Ley RE
中科院分区：
文献类型：
--
作者：
Goodrich JK;Davenport ER;Beaumont M;Jackson MA;Knight R;Ober C;Spector TD;Bell JT;Clark AG;Ley RE
对老鼠和人类的研究揭示了宿主遗传学和微生物群之间有趣的联系。在这里，我们报告了一项基于16S rRNA的对1,126对双胞胎肠道微生物组的分析，其中的一部分先前已被报道。样本的三倍缩小了遗传力估计的可信区间，并发现了更多的可遗传分类群，其中一些在其他研究中得到了验证。对受试者的重复采样表明，可遗传的类群在时间上是稳定的。一种候选基因方法揭示了可遗传分类群与与饮食、新陈代谢和嗅觉相关的基因之间的关联。我们复制了双歧杆菌和乳糖酶(LCT)基因座之间的关联，并确定了宿主基因ALDH1L1和SHA-98细菌之间的关联，这表明甲酸盐的产生和血压之间存在联系。检测到的其他基因涉及屏障防御和自我/非自我识别。我们的结果表明，饮食感知、新陈代谢和免疫防御是人类-微生物群协进化的重要驱动因素。宿主的正统类型会影响微生物群吗？古德里奇等人。介绍了对1,126对双胞胎的肠道微生物组分析，这扩大了宿主遗传学和选定的细菌分类群之间的联系。乳糖酶不持久与双歧杆菌水平较高有关。其他基因/微生物联系与饮食和屏障防御有关。
Studies in mice and humans have revealed intriguing associations between host genetics and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in 1,126 twin pairs, a subset of which was previously reported. Tripling the sample narrowed the confidence intervals around heritability estimates and uncovered additional heritable taxa, some of which are validated in other studies. Repeat sampling of subjects showed heritable taxa to be temporally stable. A candidate gene approach uncovered associations between heritable taxa and genes related to diet, metabolism and olfaction. We replicate an association between Bifidobacterium and the lactase (LCT) gene locus and identify an association between the host gene ALDH1L1 and SHA-98 bacteria, suggesting a link between formate production and blood pressure. Additional genes detected are involved in barrier defense and self/non-self recognition. Our results indicate that diet-sensing, metabolism, and immune defense are important drivers of human-microbiome co-evolution. Does host gentoype shape the microbiome? Goodrich et al. present a gut microbiome analysis of 1,126 twin pairs, which extends the association between host genetics and select bacterial taxa. Lactase nonpersistence was linked to higher levels of Bifidobacteria. Other gene/microbe links relate to diet and barrier defense.