The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes.
The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes.
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TPMT中rs1142345影响传统降糖中药治疗糖尿病前期的疗效
DOI：
10.1155/2013/327629
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Li X;Lian FM;Guo D;Fan L;Tang J;Peng JB;Deng HW;Liu ZQ;Xiao XH;Wang YR;Qu KY;Deng S;Zhong Q;Sha YL;Zhu Y;Bai YJ;Chen XY;Zhou Q;Zhou HH;Tong XL;Zhang W
糖尿病前期的治疗干预在2型糖尿病（T2D）及其慢性并发症的一级预防中非常重要。然而，很少有人知道传统草药对糖尿病前期治疗的药物遗传学作用。对194例糖耐量低减（IGT）患者进行了为期12个月的中药田七降糖治疗。对DNA样本进行了基因分型，检测了涉及药物代谢或转运的34个基因中的184个突变。多因素Logistic回归分析显示，TPMT基因rs1142345（A > G）与药物的降糖作用显著相关（P = 0.001，FDR P = 0.043）。rs1142345的“G”等位基因频率在健康组（受试者从IGT恢复至正常糖耐量）、维持组（受试者仍患有IGT）和恶化组（受试者从IGT进展至T2D）中分别为0.094、0.214和0.542。二元Logistic回归分析显示，rs1142345在健康组与维持组之间（P = 0.027，OR = 4.828）和健康组与恶化组之间（P = 0.001，OR = 7.811）也与药物的降血糖作用显著相关。因此，rs1142345与传统降糖中药的临床疗效相关。TPMT可能参与了T2D的药理学机制。
Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications. However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment. A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study. DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation. Multinomial logistic regression analysis indicated that rs1142345 (A > G) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug (P = 0.001, FDR P = 0.043). The “G” allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively. Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups (P = 0.027, OR = 4.828) and between the healthy and deterioration groups (P = 0.001, OR = 7.811). Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs. Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D.
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影响因子：
6.7
作者：
Franke RM;Lancaster CS;Peer CJ;Gibson AA;Kosloske AM;Orwick SJ;Mathijssen RH;Figg WD;Baker SD;Sparreboom A
通讯作者：
Sparreboom A
影响因子：
6.7
作者：
Otterness, D;Szumlanski, C;Weinshilboum, R
通讯作者：
Weinshilboum, R
DOI：
10.1007/978-1-60761-663-4_7
发表时间：
2010-01-01
期刊：
MICROARRAY METHODS FOR DRUG DISCOVERY
影响因子：
--
作者：
Burmester, James K.;Sedova, Marina;Mansfield, Elaine
通讯作者：
Mansfield, Elaine
影响因子：
2.1
作者：
Keskitalo, Jenni E.;Pasanen, Marja K.;Niemi, Mikko
通讯作者：
Niemi, Mikko
影响因子：
2.6
作者：
Imanaga, Junko;Kotegawa, Tsutomu;Ohashi, Kyoichi
通讯作者：
Ohashi, Kyoichi