Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography
复制标题
DOI：
10.1364/oe.16.004376
复制
发表时间：
2008-03-31
期刊：
影响因子：
3.8
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
--
作者：
Adler, Desmond C.;Huang, Shu-Wei;Fujimoto, James G.
金纳米粒子造影剂的检测证明使用光热调制技术和相敏光学相干断层扫描（OCT）。来自激光二极管的808 nm的聚焦光束在500 Hz - 60 kHz的频率下调制，同时照射含有纳米壳的溶液。由于纳米壳被设计为在808 nm处具有高吸收系数，因此激光束在调制频率下引起小尺度局部温度振荡。这些温度振荡导致光程长度变化，该光程长度变化由相敏扫频光源OCT系统检测。OCT系统使用双缓冲傅立叶域锁模（FDML）激光器，工作在1315 nm的中心波长和240 kHz的扫描速率。在含有纳米壳的体模和不含纳米壳的体模之间观察到高对比度。该技术代表了一种新的方法，用于检测金纳米粒子造影剂，具有优异的信噪比性能，在高速使用OCT。（C）2008年美国光学学会。
The detection of a gold nanoparticle contrast agent is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography (OCT). A focused beam from a laser diode at 808 nm is modulated at frequencies of 500 Hz - 60 kHz while irradiating a solution containing nanoshells. Because the nanoshells are designed to have a high absorption coefficient at 808 nm, the laser beam induces small-scale localized temperature oscillations at the modulation frequency. These temperature oscillations result in optical path length changes that are detected by a phase-sensitive, swept source OCT system. The OCT system uses a double-buffered Fourier domain mode locked (FDML) laser operating at a center wavelength of 1315 nm and a sweep rate of 240 kHz. High contrast is observed between phantoms containing nanoshells and phantoms without nanoshells. This technique represents a new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT. (C) 2008 Optical Society of America.