The place-cell representation of volumetric space in rats
The place-cell representation of volumetric space in rats
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DOI：
10.1038/s41467-020-14611-7
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发表时间：
2020-02-07
影响因子：
16.6
通讯作者：
Jeffery, Kate J.
中科院分区：
文献类型：
--
作者：
Grieves, Roddy M.;Jedidi-Ayoub, Selim;Jeffery, Kate J.
位置细胞是在海马中发现的空间调制神经元，是空间记忆和导航的基础：这些神经元如何表示3D空间对于全面理解空间认知至关重要。我们无线记录了大鼠的位置细胞，因为它们探索了一个立方体格子攀爬框架，该框架可以相对于重力对齐或倾斜。位置细胞代表迷宫的整个体积：它们的活动倾向于与迷宫轴对齐，当动物更难垂直移动时，细胞代表空间的准确性和稳定性都降低了。这些结果表明，即使是表面居住的动物也代表3D空间，并表明环境结构，重力，运动和空间记忆之间存在基本关系。
Place cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.