Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke
Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke
复制标题
DOI：
10.1016/j.jphs.2020.07.012
复制
发表时间：
2020-11-01
影响因子：
3.5
通讯作者：
Kitamura, Yoshihisa
中科院分区：
文献类型：
--
作者：
Hijioka, Masanori;Kitamura, Kanori;Kitamura, Yoshihisa
氧化应激与神经退行性疾病帕金森氏病(PD)和脑缺血的进展有关。5-氨基酮戊酸(5-ALA)是一种卟啉合成途径的中间体，近年来被报道对巨噬细胞和心肌细胞具有抗氧化作用。在此，我们用大鼠帕金森病和脑缺血模型以及体外培养的SH-SY5Y细胞证明了5-ALA的神经保护作用。5-ALA部分阻止了每种情况下的神经退行性变。这些结果表明，5-丙氨酸具有潜在的治疗药物的潜力，以防止氧化应激加剧的神经变性。(C)2020作者。由爱思唯尔B.V.代表日本药理学会制作和主办。
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.