EFFECTS OF SYNTHETIC ANTIOXIDANTS (BHA, BHT AND PG) ON THE MUTAGENICITY OF IQ-LIKE COMPOUNDS
EFFECTS OF SYNTHETIC ANTIOXIDANTS (BHA, BHT AND PG) ON THE MUTAGENICITY OF IQ-LIKE COMPOUNDS
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DOI：
10.1016/0308-8146(92)90170-7
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发表时间：
1992-01-01
期刊：
影响因子：
8.8
通讯作者：
GRAY, JI
中科院分区：
文献类型：
--
作者：
CHEN, CH;PEARSON, AM;GRAY, JI
采用Ames试验研究了酚类抗氧化剂（BHA、BHT和PG）对IQ、MeIQ和MeIQx致突变性的影响。结果表明，MeIQ、IQ和MeIQx经Ames试验均具有诱变作用，其效力顺序依次为上列。这在TA98和TA100的测试中都是正确的，两者都需要添加S-9来激活。结果表明，BHA和PG显著抑制了IQ、MeIQ和MeIQx的致突变性。另一方面，BHT在低浓度下对IQ和MeIQ的致突变性影响不大，但在高浓度下显著增加了它们的致突变性。BHT在所有浓度下均能轻微抑制MeIQx的致突变性。
This study investigated the effects of the phenolic antioxidants (BHA, BHT and PG) on the mutagenicity of IQ, MeIQ and MeIQx by the Ames test. Results demonstrated that MeIQ, IQ and MeIQx were all mutagenic when tested with the Ames test with their potency being in the order listed above. This was true on testing with both TA98 and TA100, both of which required added S-9 for activation. It was clearly demonstrated that BHA and PG significantly inhibited the mutagenicity of IQ, MeIQ and MeIQx. On the other hand, BHT had little effect on the mutagenicity of IQ and MeIQ at low concentrations, but significantly increased their mutagenicity at high concentrations. BHT slightly inhibited the mutagenicity of MeIQx at all concentrations tested.