Linking visual gamma to task-related brain networks-a simultaneous EEG-fMRI study
Linking visual gamma to task-related brain networks-a simultaneous EEG-fMRI study
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DOI：
10.1111/psyp.13462
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发表时间：
2019-08-17
期刊：
影响因子：
3.7
通讯作者：
Marek, Tadeusz
中科院分区：
文献类型：
--
作者：
Beldzik, Ewa;Domagalik, Aleksandra;Marek, Tadeusz
由于其与神经元群体的直接联系、与许多认知过程的关联以及与fMRI BOLD信号的正相关性，人们对人类γ-波段振荡活动的兴趣越来越大。视觉伽马已成功地检测到使用并发EEG-fMRI记录和链接到视觉皮层的活动，使用体素回归分析。由于伽玛波段振荡主要反映大脑区域之间的前馈投射，因此强烈建议将其纳入功能连接分析;然而，很少有研究调查这一系列研究。在目前的研究中，我们的目的是探索这一差距，询问哪些功能磁共振成像脑网络与颜色辨别任务诱导的伽马活动有关。先进的去噪策略和多锥度谱分解被应用到EEG数据检测伽马振荡，和组独立成分分析进行功能磁共振成像数据，以确定任务相关的神经网络。尽管只使用没有运动反应的试验（50%的试验），这两个神经措施成功地耦合。其中的六个任务相关的网络，枕-顶网络，表现出显着的试验与伽玛振荡的协变。除了预期的纹外视皮层，该网络还包括楔前叶、双侧顶内叶和前岛叶皮层的广泛大脑激活。我们认为，视觉皮层是伽马的来源，而其余的大脑区域表现出前馈和反馈连接，这种振荡活动。我们的研究结果为BOLD信号揭示的连接性的电生理基础提供了证据，并为颜色辨别的神经机制提供了新的见解。
There is a growing interest in human gamma-band oscillatory activity due to its direct link to neuronal populations, its associations with many cognitive processes, and its positive relationship with fMRI BOLD signal. Visual gamma has been successfully detected using concurrent EEG-fMRI recordings and linked to activity in the visual cortex using voxel-wise regression analysis. As gamma-band oscillations reflect predominantly feedforward projections between brain regions, its inclusion in functional connectivity analysis is highly recommended; however, very few studies have investigated this line of research. In the current study, we aimed to explore this gap by asking which fMRI brain network is related to gamma activity induced by the color discrimination task. Advanced denoising strategies and multitaper spectral decomposition were applied to EEG data to detect gamma oscillations, and group independent component analysis was performed on fMRI data to identify task-related neural networks. Despite using only trials without motor response (50% of the trials), the two neural measures were successfully coupled. One of the six task-related networks, the occipito-parietal network, exhibited significant trial-by-trial covariations with gamma oscillations. In addition to the expected extrastriate visual cortex, the network encompasses extensive brain activations in the precuneus, bilateral intraparietal, and anterior insular cortices. We argue that the visual cortex is the source of gamma, whereas the remaining brain regions exhibit feedforward and feedback connections related to this oscillatory activity. Our findings provide evidence for the electrophysiological basis of the connectivity revealed by BOLD signal and impart novel insights into the neural mechanism of color discrimination.