Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment.
Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment.
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DOI：
10.3390/molecules16064567
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发表时间：
2011-06-03
期刊：
影响因子：
--
通讯作者：
Skalko-Basnet N
中科院分区：
文献类型：
--
作者：
Basnet P;Skalko-Basnet N
临床前研究已经指出氧化损伤和炎症是癌症和其他慢性疾病如糖尿病、高血压、阿尔茨海默病等的根本原因。流行病学和临床研究表明，用抗氧化和抗炎药物治疗可以预防或显著减少癌症，因此，姜黄素是姜黄（一种咖喱香料）的主要成分，具有很强的抗氧化和抗炎活性，可能是预防和/或治疗癌症和其他慢性疾病的潜在候选者。然而，姜黄素作为一种高度多效性的分子，在分子水平上具有针对多种疾病的良好安全性和强有力的证据，在过去的临床试验中未能达到最佳治疗效果，主要原因是其溶解度低和生物利用度差。姜黄素可以作为一种治疗药物，通过改进配方性质或传递系统，使其增强吸收和细胞摄取。本文主要综述了姜黄素的抗炎潜力，以及姜黄素在剂量形式和纳米颗粒输送系统方面的最新进展，以及姜黄素在预防和/或治疗癌症方面的治疗应用的可能性。
Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.
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影响因子：
3.5
作者：
Adams, BK;Ferstl, EM;Shoji, M
通讯作者：
Shoji, M
DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
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5.1
作者：
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影响因子：
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作者：
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