The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
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DOI：
10.1136/gut.50.4.471
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发表时间：
2002-04-01
期刊：
影响因子：
24.5
通讯作者：
Whorwell, PJ
中科院分区：
文献类型：
--
作者：
Houghton, LA;Lea, R;Whorwell, PJ
背景：我们之前已经表明，月经周期对正常健康女性的直肠敏感性没有影响，尽管她们在月经时大便较松。肠易激综合征(IBS)患者经常报告随着月经期IBS症状的显著恶化，这增加了IBS患者对月经周期的不同反应的可能性。目的和方法：对29例女性IBS患者(年龄21-44岁)在月经周期的第1-4天(月经期)、8-10天(卵泡期)、18-20天(黄体期)和24-28天(经前期)对直肠扩张的反应进行评估。在研究过程中，患者完成症状日记，以评估腹痛和腹胀(视觉模拟评分)，以及排便习惯的频率和一致性。结果：与大多数月经周期的其他阶段相比，月经与腹痛和腹胀的加重有关(p
Background: We have previously shown that the menstrual cycle has no effect on rectal sensitivity of normal healthy women, despite them having looser stools at the time of menses. Patients with irritable bowel syndrome (IBS) often report significant exacerbation of their IBS symptoms with menses, raising the possibility that IBS patients may respond differently to the menstrual cycle.Aim and methods: Rectal responses to balloon distension during days 1-4 (menses), 8-10 (follicular phase), 18-20 (luteal phase), and 24-28 (premenstrual phase) of the menstrual cycle were assessed in 29 female IBS patients (aged 21-44 years), diagnosed by the Rome I criteria. During the course of the study patients completed symptom diaries to assess abdominal pain and bloating (visual analogue scale), and frequency and consistency of bowel habits. In addition, levels of anxiety and depression were assessed using the hospital anxiety and depression questionnaire.Results: Menses was associated with a worsening of abdominal pain and bloating compared with most other phases of the menstrual cycle (p