G protein-coupled receptors cooperate to silence dopamine neurons.
G protein-coupled receptors cooperate to silence dopamine neurons.
复制标题
G 蛋白偶联受体协同作用来沉默多巴胺神经元。
DOI：
10.1113/jp283842
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Tritsch,NicolasX
中科院分区：
文献类型：
--
作者：
Liu,Haixin;Tritsch,NicolasX
哺乳动物的中脑深处有一小群神经元，它们释放化学物质多巴胺（DA），以激发行为和促进学习的能力而闻名。关键词：氨基丁酸；基底神经节;多巴胺;作为脊椎动物中最大的信号受体家族，G蛋白偶联受体（gpcr）在使细胞对多种细胞外因子（从血液中的激素到心脏和大脑中的小分子递质，一直到化学气味剂甚至光子）做出反应方面发挥着关键作用。G蛋白偶联受体合作使多巴胺神经元沉默。[文章节选]
Deep in the mammalian midbrain lies a small population of neurons that release the chemical dopamine (DA) and that are famous for their ability to motivate behaviour and promote learning. Keywords: aminobutyric acid; basal ganglia; dopamine; ion channel modulation EN aminobutyric acid basal ganglia dopamine ion channel modulation 4773 4774 2 11/17/22 20221115 NES 221115 As the largest family of signalling receptors in vertebrates, G protein-coupled receptors (GPCRs) play a pivotal role in enabling cells to respond to a diverse range of extracellular factors, from hormones in the blood, to small molecule transmitters in the heart and brain, all the way to chemical odorants and even photons. G protein-coupled receptors cooperate to silence dopamine neurons.[Extracted from the article]