18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
复制标题
18F-DOPA正电子发射断层扫描/计算机断层扫描在先天性高胰岛素血症中的应用
DOI：
10.1515/jpem-2012-0114
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发表时间：
2012
影响因子：
6.5
通讯作者：
R. Hao
中科院分区：
文献类型：
--
作者：
Ji;Leilei Yuan;J. Meeks;N. Zhang;Chunlin Li;R. Hao
摘要 婴儿期先天性高胰岛素血症（CHI）的特点是胰岛素分泌不当，导致持续性低血糖。这可能会导致婴儿出现不可逆转的严重神经损伤。有两种主要的组织学亚型：弥漫性和局灶性，这两种亚型可能需要不同的手术策略。区分局灶性病变和弥漫性病变非常重要。然而，区分弥漫性病变和局灶性病变具有挑战性。受影响的胰腺区域利用二羟基苯丙氨酸（DOPA）的比率高于正常胰腺组织；因此，用氟 18 (18F-DOPA) 标记 L-DOPA 可以使用正电子发射断层扫描/计算机断层扫描 (PET/CT) 进行高胰岛素血症的功能图谱。在本文中，我们回顾了 18F-DOPA PET/CT 在 CHI 中的应用。本综述的目的是提高18F-DOPA PET/CT在CHI诊断中应用的认识。
Abstract Congenital hyperinsulinism (CHI) during infancy is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia. This can lead to irreversible severe neurological damage in the infant. There are two main histologic subtypes: diffuse and focal, both of which may require different surgical strategies. It is very important to differentiate focal leisons from diffuse leisons. However, the differentiation of diffuse leisons from focal leisons is challenging. Affected pancreatic areas utilize dihydroxyphenylalanine (DOPA) at a higher rate than normal pancreatic tissues; thus, labeling of L-DOPA with fluorine-18 (18F-DOPA) allows functional mapping of hyperinsulinism using positron emission tomography/computed tomography (PET/CT). In this article, we reviewed the 18F-DOPA PET/CT application in CHI. The aim of this review is to enhance the recognition of 18F-DOPA PET/CT application in the diagnosis of CHI.