Cytokines are associated with postembolization fever and survival in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization
Cytokines are associated with postembolization fever and survival in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization
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DOI：
10.1007/s12072-012-9409-9
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发表时间：
2013-07-01
影响因子：
6.6
通讯作者：
Li, Chung-Pin
中科院分区：
文献类型：
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作者：
Chao, Yee;Wu, Chen-Yi;Li, Chung-Pin
细胞因子在血管生成、炎症和细胞生长中起重要作用。为探讨肝细胞癌（HCC）患者行肝动脉化疗栓塞术（TACE）后细胞因子变化与临床特征的关系，选取41例接受TACE治疗的HCC患者和30例健康对照者，共行TACE 73次。血清肿瘤坏死因子-α水平肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、血管生成素、表皮生长因子（EGF）、表皮生长因子受体和转化生长因子β 1结果HCC患者术前、术后1、3、5、7、14 d血清VEGF、bFGF、IL-6、IL-8、TNF-α水平显著升高，而EGF和TGF-β 1水平与健康对照组相比较低（均为p < 0.05）。血清IL-6迅速升高，并在TACE给药后第1天达到峰值，而VEGF升高较慢，并在TACE给药后第14天达到峰值。TACE术后发热患者在第1、3和5天血清IL-6水平较高（所有患者p < 0.005）。TACE前血清VEGF < 200 pg/ml的患者比TACE前血清VEGF水平<200 pg/ml的患者生存期更长（22.2个月vs. 11.6个月，p = 0.014）。考克斯多变量分析显示，基线血清VEGF显著预测接受TACE的HCC患者的生存率。TACE与HCC患者血清血管生成、炎症和细胞生长细胞因子的调节相关。血清IL-6与TACE后发热相关，基线血清VEGF独立预测患者生存。
Cytokines play important roles in angiogenesis, inflammation, and cell growth. The present study aimed to investigate the correlation between cytokine changes and clinical characteristics in hepatocellular carcinoma (HCC) patients receiving transcatheter arterial chemoembolization (TACE).Forty-one TACE-naive HCC patients receiving 73 sessions of TACE and 30 healthy controls were studied. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, epidermal growth factor (EGF), epidermal growth factor receptor, and transforming growth factor beta 1 (TGF-beta 1) before and at 1, 3, 5, 7, and 14 days after TACE as well as clinical parameters were analyzed.Baseline serum levels of VEGF, bFGF, IL-6, IL-8, and TNF-alpha in HCC patients were significantly elevated, whereas EGF and TGF-beta 1 levels were lower compared to those in healthy controls (p < 0.05 for all). Serum IL-6 increased rapidly and peaked on day 1 after TACE administration, whereas VEGF increased more slowly and peaked on day 14 after TACE administration. Patients with post-TACE fever had higher serum IL-6 levels on days 1, 3, and 5 (p < 0.005 for all). Patients with pre-TACE serum VEGF < 200 pg/ml had a longer survival than those with pre-TACE serum VEGF levels a parts per thousand yen 200 pg/ml (22.2 months vs. 11.6 months, p = 0.014). Cox multivariate analysis showed that baseline serum VEGF significantly predicted survival for HCC patients receiving TACE.TACE is associated with the modulation of serum angiogenic, inflammatory, and cell growth cytokines in HCC patients. Serum IL-6 correlates with post-TACE fever, and baseline serum VEGF independently predicts patient survival.