Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation
Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation
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DOI：
10.1016/s0002-9440(10)63005-2
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发表时间：
2001-11-01
影响因子：
6
通讯作者：
Masliah, E
中科院分区：
文献类型：
--
作者：
Chen, Q;Yoshida, H;Masliah, E
一种新的早老素结合蛋白，PBP，最近已被确定。PBP定位于阿尔茨海默病脑提取物的颗粒级分，但在年龄匹配的正常对照的脑的可溶级分中发现。这里显示PBP与阿尔茨海默病大脑中的神经元缠结相关。此外，PBP的表达增加了培养细胞中tau的磷酸化。因此，PBP可能在tau蛋白磷酸化和神经元缠结的发生中具有调节作用。
A novel presenilin binding protein, PBP, has recently been identified. PBP is localized to the particulate fraction of extracts of Alzheimer's disease brain but is found in the soluble fractions of brain from age matched normal controls. It is shown here that PBP is associated with neurofibrillary tangles in Alzheimer's disease brain. In addition, the expression of PBP increases the phosphorylation of tau in cultured cells. Therefore PBP may have a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles.