Frontal Cortical and Subcortical Projections Provide a Basis for Segmenting the Cingulum Bundle: Implications for Neuroimaging and Psychiatric Disorders
Frontal Cortical and Subcortical Projections Provide a Basis for Segmenting the Cingulum Bundle: Implications for Neuroimaging and Psychiatric Disorders
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DOI：
10.1523/jneurosci.5459-13.2014
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发表时间：
2014-07-23
影响因子：
5.3
通讯作者：
Haber, Suzanne N.
中科院分区：
文献类型：
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作者：
Heilbronner, Sarah R.;Haber, Suzanne N.
扣带束 (CB) 是大脑的主要白质通路之一，连接与执行功能、决策和情感相关的区域。神经影像学显示，CB 内特定部位的异常与特定的精神疾病有关，包括抑郁症和双相情感障碍。然而，使用 CB 各部分的纤维仍然未知。在这项研究中，我们使用非人类灵长类动物（猕猴、食蟹猴、猕猴）的解剖束追踪来检查通过 CB 的特定扣带回、非扣带回额叶和皮质下通路的组织。目标如下：(1) 确定使用 CB 的连接，(2) 确定这些纤维穿过 CB 的哪些部分，以及 (3) 将 CB 纤维路径与人类中确定为改善精神疾病的神经外科目标的 CB 部分联系起来。结果表明，扣带回、非扣带回额叶和皮质下纤维均穿过 CB 到达扣带回和非扣带回目标。然而，许多大脑区域仅通过部分而不是全部 CB 发送投射。例如，杏仁核纤维不存在于背侧 CB 的尾部。这些结果允许将 CB 分割为四个独特的区域。我们确定了精神疾病中异常的特定连接以及受神经外科干预措施（例如深部脑刺激和扣带回切开术）影响的特定连接。
The cingulum bundle (CB) is one of the brain's major white matter pathways, linking regions associated with executive function, decision-making, and emotion. Neuroimaging has revealed that abnormalities in particular locations within the CB are associated with specific psychiatric disorders, including depression and bipolar disorder. However, the fibers using each portion of the CB remain unknown. In this study, we used anatomical tract-tracing in nonhuman primates (Macaca nemestrina, Macaca fascicularis, Macaca mulatta) to examine the organization of specific cingulate, noncingulate frontal, and subcortical pathways through the CB. The goals were as follows: (1) to determine connections that use the CB, (2) to establish through which parts of the CB these fibers travel, and (3) to relate the CB fiber pathways to the portions of the CB identified in humans as neurosurgical targets for amelioration of psychiatric disorders. Results indicate that cingulate, noncingulate frontal, and subcortical fibers all travel through the CB to reach both cingulate and noncingulate targets. However, many brain regions send projections through only part, not all, of the CB. For example, amygdala fibers are not present in the caudal portion of the dorsal CB. These results allow segmentation of the CB into four unique zones. We identify the specific connections that are abnormal in psychiatric disorders and affected by neurosurgical interventions, such as deep brain stimulation and cingulotomy.