Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study.
Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study.
复制标题
DOI：
10.1038/sj.bjc.6605768
复制
发表时间：
2010-07-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
芳香化酶抑制剂（AI）相关的肌肉骨骼综合征（AIMSS）发生在大约50%的AI治疗的患者。炎症介质与雌激素信号传导相关，并可能随着雌激素消耗而变化。我们假设AIMSS可能与循环炎症标志物的变化有关。乳腺癌患者参加了一项辅助AI治疗试验。前瞻性评估治疗期间疼痛和功能的变化。我们选择了30例患有AIMSS的患者和22例没有AIMSS的对照，人口统计学和既往治疗相匹配。在基线和治疗期间收集的血清样品使用多重测定法测定多种炎性细胞因子和脂质介质。AI治疗前，病例组血清36项指标中有6项的平均浓度显著低于对照组（P均<0.003）。在AI治疗期间，相对于治疗前，在病例和对照组之间未观察到任何检测的炎症标志物的统计学显著变化。AIMSS可能与全身炎症反应无关。治疗前细胞因子水平可以预测AIMSS的发展。
The aromatase inhibitor (AI)-associated musculoskeletal syndrome (AIMSS) occurs in approximately 50% of AI-treated patients. Inflammatory mediators are associated with oestrogen signalling and may change with oestrogen depletion. We hypothesised that AIMSS may be associated with changes in circulating inflammatory markers. Patients with breast cancer were enroled in a trial of adjuvant AI therapy. Changes in pain and function during therapy were assessed prospectively. We selected 30 cases with AIMSS and 22 controls without AIMSS, matched for demographics and prior therapy. Serum samples collected at baseline and during treatment were assayed for multiple inflammatory cytokines and lipid mediators using multiplex assays. Before AI therapy, mean serum concentrations of 6 of 36 assayed factors were statistically significantly lower in cases than controls (all P<0.003). No statistically significant changes during AI therapy relative to pre-treatment were observed between cases and controls for any of the inflammatory markers tested. AIMSS is probably not associated with a systemic inflammatory response. Pre-treatment cytokine levels may predict for development of AIMSS.
登录
查看更多内容
影响因子：
20.3
作者：
Bower, Mark;Veraitch, Ophelia;Stebbing, Justin
通讯作者：
Stebbing, Justin
影响因子：
45.3
作者：
Morales, Leilani;Pans, Steven;Neven, Patrick
通讯作者：
Neven, Patrick
影响因子：
45.3
作者：
Geisler, J;Haynes, B;Lonning, PE
通讯作者：
Lonning, PE
影响因子：
45.3
作者：
Coates, Alan S.;Keshaviah, Aparna;Goldhirsch, Aron
通讯作者：
Goldhirsch, Aron
影响因子：
3.8
作者：
Henry, N. Lynn;Giles, Jon T.;Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.