Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel
Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel
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DOI：
10.1111/j.1748-5827.2006.00107.x
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发表时间：
2006-09-01
影响因子：
1.6
通讯作者：
Barnett, K. C.
中科院分区：
文献类型：
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作者：
Barnett, K. C.
目的：记录先前未报告的影响查理王小猎犬眼睛和皮肤的先天性和遗传性疾病。方法：对 19 例（13 窝）进行了调查，特别是眼睛和皮肤的临床症状。此外，还获得了除一例之外的所有病例的五代谱系并进行了研究。 结果：眼部症状是由于干燥性角结膜炎引起的，这是狗的常见眼部疾病，但很少是先天性的。皮肤症状为鱼鳞病样皮肤病；鱼鳞病是一种罕见的狗皮肤病。在人类中，鱼鳞病是一种类似的疾病，主要是遗传性的，新生儿发病，有时还伴有其他发育缺陷。在骑士查理王小猎犬中，饲养员在出生时就注意到其毛发异常为“卷曲毛发”，随着动物成年，皮肤迹象逐渐恶化。临床意义：一些饲养员充分认识到这两种情况同时发生，但兽医界却很少认识到。尽管可以获得一些改善，特别是干燥性角结膜炎，但成功的治疗是不可能的。该病症可能的遗传性质是控制的一个重要因素。
Objectives: To record a previously unreported congenital and hereditary condition affecting the eyes and skin in the cavalier King Charles spaniel.Methods: Nineteen cases (13 litters) were investigated, with particular reference to eye and skin clinical signs. In addition, five generation pedigrees were obtained and studied from all cases with the exception of one.Results: The eye signs were due to keratoconjunctivitis sicca, a common ocular disease in the dog, but rarely of congenital origin. The skin signs were of an ichthyosiform dermatosis; ichthyosis being a rare skin disease in the dog. In human beings, ichthyosis is a similar disease, mainly inherited and with a neonatal onset, and sometimes accompanied by other developmental defects. In the cavalier King Charles spaniel, the coat abnormality was noted at birth by the breeders as a 'curly coat', with deterioration of the skin signs as the animal became adult.Clinical Significance: These two conditions occurring together in this breed is well recognised by some breeders but rarely by the veterinary profession. Successful treatment is not possible, although some improvement, particularly of the keratoconjunctivitis sicca, can be obtained. The probable hereditary nature of the condition is an important factor for control.