An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications
An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications
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DOI：
10.3390/mi11030300
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发表时间：
2020-03-01
期刊：
影响因子：
3.4
通讯作者：
Lee, Jeong-Bong
中科院分区：
文献类型：
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作者：
Chen, Ziyu;Noh, Sunggi;Lee, Jeong-Bong
研究发现，调节骨髓腔内的液体流动可以刺激骨细胞活动，促进骨生长。然而，对液体调节效果的研究仅限于通过皮肤管道连接到骨髓腔的外部注射器泵。我们报道了一种适用于啮齿动物体内研究的植入式磁性微流体泵。用不锈钢模具在聚二甲基硅氧烷(PDMS)中制作了一种紧凑型NdFeB磁体微流体泵(直径22 mm，厚度5 mm)。使用带有较大磁体的外部致动器来无线致动磁性微流体泵。对微流控泵静压随磁铁尺寸变化的特性进行了评估。并对泵的动态压力进行了表征，以估算泵的出力。将磁性微流体泵植入Fischer-344大鼠的背部，并通过管子连接到股骨的髓内腔。使用体外致动器的按需无线磁操作被发现在大鼠的股骨髓内腔内诱导高达38毫米汞的压力调制。
Modulations of fluid flow inside the bone intramedullary cavity has been found to stimulate bone cellular activities and augment bone growth. However, study on the efficacy of the fluid modulation has been limited to external syringe pumps connected to the bone intramedullary cavity through the skin tubing. We report an implantable magnetic microfluidic pump which is suitable for in vivo studies in rodents. A compact microfluidic pump (22 mm diameter, 5 mm in thickness) with NdFeB magnets was fabricated in polydimethylsiloxane (PDMS) using a set of stainless-steel molds. An external actuator with a larger magnet was used to wirelessly actuate the magnetic microfluidic pump. The characterization of the static pressure of the microfluidic pump as a function of size of magnets was assessed. The dynamic pressure of the pump was also characterized to estimate the output of the pump. The magnetic microfluidic pump was implanted into the back of a Fischer-344 rat and connected to the intramedullary cavity of the femur using a tube. On-demand wireless magnetic operation using an actuator outside of the body was found to induce pressure modulation of up to 38 mmHg inside the femoral intramedullary cavity of the rat.