Human platelet antigens in disease.
Human platelet antigens in disease.
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DOI：
10.1016/j.cca.2018.05.009
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Ying-hao Wen;Ding-Ping Chen
中科院分区：
文献类型：
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作者：
Ying-hao Wen;Ding-Ping Chen
血小板具有多种功能，参与初级止血、炎症和免疫反应。人血小板抗原（HPAs）是在血小板膜上表达的异体抗原。每个HPA代表六种血小板糖蛋白GPIIb、GPIIIa、gpiia、GPIbα、GPIbβ和CD109中的一种，并将六个双等位基因系统分组。基因序列中的单核苷酸多态性（SNP）导致相关血小板糖蛋白（HPA-14bw除外）的单氨基酸替代。基于高通量的新一代测序方法的开发，使HPA多态性的准确鉴定成为可能。综述了HPA在疾病中的作用。HPAs介导血小板与微生物、血小板与恶性细胞的相互作用，参与肾综合征出血热、感染性心内膜炎的发病机制。探索与个体疾病易感性相关的HPA多态性将有助于疾病的预防或管理。
Platelets have various functions and participate in primary hemostasis, inflammation, and immune responses. Human platelet antigens (HPAs) are alloantigens expressed on the platelet membrane. Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped. A single nucleotide polymorphism (SNP) in the gene sequence causes a single amino acid substitution of relevant platelet glycoprotein with the exception of HPA-14bw. High-throughput next-generation sequencing-based method has been developed, which enable accurately identification of HPA polymorphisms. The roles of HPA in disease were reviewed. HPAs mediate platelet-microorganism and platelet-malignant cell interactions, and they also participate in pathogenesis of hemorrhagic fever with renal syndrome and infective endocarditis. The exploration of HPA polymorphisms in association with disease susceptibility of individuals will benefit prevention or management of disease.