Drugging the efferocytosis process: concepts and opportunities.
Drugging the efferocytosis process: concepts and opportunities.
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DOI：
10.1038/s41573-022-00470-y
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发表时间：
2022-08
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影响因子：
--
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中科院分区：
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--
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每天通过红细胞增多症的过程去除人体中数十亿的凋亡细胞对于体内平衡是必不可少的。为了允许这种连续的细胞吞噬作用，吞噬细胞中发生快速的表型变化，使它们能够吞噬和消化凋亡货物。此外，红细胞增多症是积极抗炎和促进决议。由于其普遍存在的性质和细胞周转的绝对量，红细胞增多症是一个脆弱点。红细胞增多症的异常与许多炎性病理学有关，包括动脉粥样硬化、癌症和感染。最近令人兴奋的发现，定义参与红细胞增多症的分子机制，开辟了许多途径的治疗干预，目前有几种药物在临床试验。红细胞增多症的异常与许多炎性病理学有关，包括动脉粥样硬化、癌症和感染。在这里，Mehrotra和Ravichandran讨论了红细胞增多症的机制和这种生理过程在疾病中的作用，并评估了治疗干预的策略和药物。
The daily removal of billions of apoptotic cells in the human body via the process of efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid phenotypic changes occur in the phagocytes enabling them to engulf and digest the apoptotic cargo. In addition, efferocytosis is actively anti-inflammatory and promotes resolution. Owing to its ubiquitous nature and the sheer volume of cell turnover, efferocytosis is a point of vulnerability. Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infections. The recent exciting discoveries defining the molecular machinery involved in efferocytosis have opened many avenues for therapeutic intervention, with several agents now in clinical trials. Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infections. Here, Mehrotra and Ravichandran discuss the mechanisms of efferocytosis and the role of this physiological process in disease, and assess strategies and agents for therapeutic intervention.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
7.3
作者：
Billings EA;Lee CS;Owen KA;D'Souza RS;Ravichandran KS;Casanova JE
通讯作者：
Casanova JE
影响因子：
4.6
作者：
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通讯作者：
Walsh, K.
DOI：
10.1073/pnas.1524292113
发表时间：
2016-06-07
影响因子：
11.1
作者：
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通讯作者：
Tabas, Ira
影响因子：
15.9
作者：
Cai, Bishuang;Thorp, Edward B.;Tabas, Ira
通讯作者：
Tabas, Ira