Wittig gem-difluoroolefination of aldehydes with difluoromethyltriphenylphosphonium bromide
Wittig gem-difluoroolefination of aldehydes with difluoromethyltriphenylphosphonium bromide
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醛与二氟甲基三苯基溴化鏻的 Wittig 偕二氟烯化反应
DOI：
10.1016/j.jfluchem.2014.04.011
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发表时间：
2014-07-01
影响因子：
1.9
通讯作者：
Xiao, Ji-Chang
中科院分区：
文献类型：
--
作者：
Li, Qiang;Lin, Jin-Hong;Xiao, Ji-Chang
本文报道了醛与溴化二氟甲基三苯基膦的Wittig反应，以中等产率得到偕二氟烯烃。该反应具有良好的底物范围，包括芳基、杂芳基和α，β-不饱和醛。二氟甲基三苯基溴化鏻易于制备，在空气气氛下可长期保存。通过热重分析证明该盐具有高的热稳定性。其结构通过核磁共振谱和单晶X-射线衍射分析证实。(C)2014爱思唯尔有限公司版权所有。
Wittig reaction of aldehydes with difluoromethyltriphenylphosphonium bromide leading to gem-difluoroolefins in moderate yields is described. The reaction displays a good substrate scope including aryl, heteroaryl and alpha,beta-unsaturated aldehydes. Difluoromethyltriphenylphosphonium bromide could be easily prepared and stored for a long time under air atmosphere. The salt exhibits high thermal stability demonstrated by thermogravimetric analysis. Its structure was confirmed by NMR spectroscopy and single crystal X-ray analysis. (C) 2014 Elsevier B.V. All rights reserved.