A role of mast cells for hepatic fibrosis in primary sclerosing cholangitis
A role of mast cells for hepatic fibrosis in primary sclerosing cholangitis
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DOI：
10.1016/j.hepres.2005.01.007
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发表时间：
2005-03-01
影响因子：
4.2
通讯作者：
Arizono, N
中科院分区：
文献类型：
--
作者：
Ishii, A;Iwai, M;Arizono, N
我们遇到了四名明显的原发性硬化性胆管炎（PSC）患者，其组织学分为2期或3期。我们通过免疫组织化学检查了受损胆管中c-kit配体干细胞因子（SCF）的表达，并使用抗HMCT（人肥大细胞类胰蛋白酶）和抗e-kit抗体通过免疫组织化学鉴定肥大细胞以澄清 它们与门静脉纤维化的关系与胆管破坏一致。 PSC 中大多数胆管上皮中检测到 SCF，在汇管束中发现许多 HMCT 和 c-kit 阳性肥大细胞。图像分析显示，PSC 汇管区每个区域的 c-kit 阳性肥大细胞数量比慢性丙型肝炎更显着，并且可能从第 2 期增加到第 3 期。c-Kit 阳性细胞浸润到 SCF 阳性破坏胆管的汇管区，应详细研究 c-kit 肥大细胞，以了解 PSC 门管纤维化的作用。 (c) 2005 Elsevier B.V 保留所有权利。
We encountered four patients with overt primary sclerosing cholangitis (PSC) which were histologically classified into stage 2 or 3. We examined the expression of stem cell factor (SCF), a ligand of c-kit, in injured bile ducts by immunohistochemistry, and mast cells were identified by immunohistochemistry using anti-HMCT (human mast cell tryptase) and anti-e-kit antibodies to clarify their relation with portal fibrosis coincident with destroyed bile ducts. SCF was detected in the epithelia of most bile ducts in PSC, and many HMCT- and c-kit-positive mast cells were found in portal tracts. Image analysis showed more significant numbers of c-kit-positive mast cells per area of portal tract in PSC than in chronic hepatitis C, and they might increase from stage 2 to 3. c-Kit-positive cells infiltrated into the portal tracts with SCF-positive destroyed bile ducts, and c-kit mast cells should be investigated in detail to make a role for portal fibrosis in PSC. (c) 2005 Elsevier B.V All rights reserved.