THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION
THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION
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DOI：
10.1038/362761a0
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发表时间：
1993-04-22
期刊：
影响因子：
64.8
通讯作者：
SHORTMAN, K
中科院分区：
文献类型：
--
作者：
ARDAVIN, C;WU, L;SHORTMAN, K
树突状细胞是淋巴组织中的次要细胞群，专门用于将抗原肽呈现给T淋巴细胞1。胸腺树突状细胞参与自反应性T淋巴细胞的缺失2,3。尽管所有的树突状细胞最终都是骨髓来源4-7，但尚不清楚胸腺树突状细胞是在成年胸腺中从前体细胞中产生的，还是它们是否从外围迁移到那里。最近，我们从成年小鼠胸腺A分离出来的早期T前体的群体，这些前体可能仍会形成B淋巴细胞，但不能形成红细胞，但不能形成红细胞或髓样细胞，当静脉内转移8,9时。在这里，我们表明，当转移到辐照的胸腺中时，这些胸腺淋巴前体细胞以及骨髓造血干细胞能够形成树突状细胞和T细胞后代。这种连接的发育可以确保在新形成的胸腺树突状细胞上呈现的自抗原主要选择发育的T细胞。
DENDRITIC cells, a minor cell population in lymphoid tissues, are specialized for presentation of antigenic peptides to T lymphocytes1. Thymic dendritic cells are involved in the deletion of self-reactive T lymphocytes2,3. Although all dendritic cells are ultimately of bone-marrow origin4-7, it has not been clear whether thymic dendritic cells are produced in the adult thymus from a precursor cell or whether they migrate there preformed from the periphery. Recently we isolated from adult mouse thymus a population of early T precursors that could still form B lymphocytes, but not erythroid or myeloid cells, when transferred intravenously8,9. Here we show that these thymic lymphoid precursor cells, as well as bone-marrow haematopoietic stem cells, are able to form both dendritic cells and T-cell progeny when transferred into an irradiated thymus. Such linked development may ensure that developing T cells are negatively selected predominantly by self antigens presented on newly formed thymic dendritic cells.