BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells
BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells
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DOI：
10.2116/analsci.32.543
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发表时间：
2016-05
影响因子：
1.6
通讯作者：
Akira Tsuchiya;S. N. Hashim;Shoko Ise;Takafumi Furuhata;K. Kawai;R. Wakabayashi;M. Goto;N. Kamiya-N.-K
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文献类型：
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作者：
Akira Tsuchiya;S. N. Hashim;Shoko Ise;Takafumi Furuhata;K. Kawai;R. Wakabayashi;M. Goto;N. Kamiya-N.-K
细胞内适配子传感器有可能通过信号分子揭示细胞间的通讯。我们试图设计新的荧光适体传感器来检测细胞上的干扰素-γ和腺嘌呤化合物。BODIPY标记的外部无猝灭剂适配子传感器允许对目标分子进行开启检测，并提高了关闭/开启效率。
An on-cell aptamer sensor has the potential to reveal cell-cell communications by signalling molecules. We attempted to design new fluorescent aptamer sensors for the sensing of IFN- γ and adenine compounds on cells. BODIPY-labeled external quencher-free aptamer sensors have allowed a turn-on detection of the target molecule with improved off/on efficiency.