Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease
Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease
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DOI：
10.1093/humrep/13.7.1957
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发表时间：
1998-07-01
影响因子：
6.1
通讯作者：
Kingsland, CR
中科院分区：
文献类型：
--
作者：
Gazvani, MR;Christmas, S;Kingsland, CR
越来越多的证据表明，免疫机制在子宫内膜异位症的发病机制和病理生理中发挥作用。因此，它是感兴趣的研究白细胞介素-8（IL-8），一种趋化因子，在腹腔镜手术的妇女的腹腔液和外周血。评估了IL-8的存在和浓度与子宫内膜异位症、不孕症和腹痛的关系。从50例因各种妇科适应症接受腹腔镜手术的连续患者中获得腹腔液（n = 49）和外周血（n = 50）样本（腹痛、不孕、绝育），大多数女性（87%）的腹腔液中存在IL-8，子宫内膜异位症患者腹腔液中IL-8的浓度高于非子宫内膜异位症患者。（P = 0.02），这种差异在早期（第1期）子宫内膜异位症中更为明显（P = 0.001）。早期子宫内膜异位症患者的腹腔液中IL-8浓度也高于晚期子宫内膜异位症患者（P = 0.003）。外周血IL-8浓度与腹腔液中IL-8浓度和/或子宫内膜异位症的存在无关。结论：IL-8可能通过促进新生血管的形成而参与子宫内膜异位症的发病，为子宫内膜异位症的治疗提供了新的思路。
There is increasing evidence that immunological mechanisms play a role in the pathogenesis and pathophysiology of endometriosis. It was therefore of interest to study interleukin-8 (IL-8), a chemokine, in the peritoneal fluid and peripheral blood of women undergoing laparoscopic procedures. The presence and concentrations of IL-8 in relation to endometriosis, infertility and abdominal pain were evaluated. Samples of peritoneal fluid (n = 49) and peripheral blood (n = 50) were obtained from 50 consecutive patients undergoing laparoscopic surgery for various gynaecological indications (abdominal pain, infertility, sterilization), IL-8 was present in the peritoneal fluid of most women (87%), The concentration of IL-8 in the peritoneal fluid was higher in women with endometriosis compared to women without (P = 0.02), This difference was more pronounced in early (stage 1) endometriosis (P = 0.001). IL-8 concentrations in the peritoneal fluid were also higher in women with early endometriosis compared to women with later stages of the disease (P = 0.003), Peripheral blood concentrations did not correlate with peritoneal fluid concentrations of IL-8 and/or the presence of endometriosis. We conclude that IL-8 is an important factor that may contribute to the pathogenesis of endometriosis possibly by promoting neovascularization, This information can be a guide in the development of new therapeutic approaches for the treatment of endometriosis.