Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy
Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy
复制标题
可生物降解的中空介孔有机二氧化硅纳米治疗剂用于温和热疗诱导气泡增强氧敏放射治疗
DOI：
10.1021/acsnano.7b08103
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发表时间：
2018-02-01
期刊：
影响因子：
17.1
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Lu, Nan;Fan, Wenpei;Chen, Xiaoyuan
缓解肿瘤缺氧一直是提高放疗效果的前提，而放疗效果的好坏取决于肿瘤区域氧气的提前输送和快速释放。在此，我们提出了一种“气泡增强氧扩散”策略，以实现整个肿瘤氧合，从而基于“旁观者效应”显着增强辐射。为此，构建了亚 50 nm CuS 修饰和 Cu-64 标记的中空介孔有机二氧化硅纳米颗粒，用于肿瘤特异性递送 O-2 饱和全氟戊烷 (PFP)。通过近红外激光触发的温和热疗产生的 PFP 气化，可以实现同步 PET/PA/US 多模态成像和氧气在肿瘤中的快速扩散，从而实现显着的低氧放射增敏。此外，多功能载氧纳米治疗剂还允许其他氧依赖性治疗，从而极大地推进了气泡增强协同治疗平台的发展。
Alleviation of tumor hypoxia has been the premise for improving the effectiveness of radiotherapy, which hinges upon the advanced delivery and rapid release of oxygen within the tumor region. Herein, we propose a "bubble-enhanced oxygen diffusion" strategy to achieve whole tumor oxygenation for significant radiation enhancement based on the "bystander effect". Toward this end, sub-50 nm CuS-modified and Cu-64-labeled hollow mesoporous organosilica nanoparticles were constructed for tumor-specific delivery of O-2-saturated perfluoropentane (PFP). Through the aid of PFP gasification arising from NIR laser-triggered mild hyperthermia, simultaneous PET/PA/US multimodality imaging and rapid oxygen diffusion across the tumor can be achieved for remarkable hypoxic radiosensitization. Furthermore, the multifunctional oxygen-carrying nanotheranostics also allow for other oxygen-dependent treatments, thus greatly advancing the development of bubble-enhanced synergistic therapy platforms.