Genomic imprinting of a placental lactogen gene in Peromyscus.
Genomic imprinting of a placental lactogen gene in Peromyscus.
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Peromyscus 胎盘催乳素基因的基因组印记。
DOI：
10.1007/s00427-001-0188-x
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Tilghman,SM
中科院分区：
文献类型：
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作者：
Vrana,PB;Matteson,PG;Schmidt,JV;Ingram,RS;Joyce,A;Prince,KL;Dewey,MJ;Tilghman,SM
哺乳动物基因组包含30多个基因，这些基因的表达取决于它们的亲本。在这些印迹基因中，大多数与调节胎儿生长速率有关。在本报告中，我们发现在鹿鼠peromyscus中，胎盘乳原-1变异（pPl1-v）基因在整个胎儿发育过程中都是父系表达的，而与之密切相关的ppl1基因则以双等位基因的方式表达。亲缘关系较远的ppl2agene和theMus pl1基因都没有表现出父系等位基因的优先表达，这表明ppl1印记的获得是相对较近的进化事件。尽管ppl1的表达在两种虎肌物种杂交的发育不良胎盘中暂时失调，但其过度表达不能解释这些胎盘的异常表型。我们认为，ppl1 -v的物种特异性印记编码一种生长因子，调节从母亲到后代的营养转移，这与解释基因组印记进化的亲子冲突模型是一致的。
The mammalian genome contains over 30 genes whose expression is dependent upon their parent-of-origin. Of these imprinted genes the majority are involved in regulating the rate of fetal growth. In this report we show that in the deer mousePeromyscusthe placental lactogen-1-variant (pPl1-v) gene is paternally expressed throughout fetal development, whereas the linked and closely relatedpPl1gene is expressed in a biallelic manner. Neither the more distantly relatedpPl2Agene, nor theMus Pl1gene displays any preferential expression of the paternal allele, suggesting that the acquisition of imprinting ofpPl1-vis a relatively recent event in evolution. AlthoughpPl1expression is temporally mis-regulated in the dysplastic placentae of hybrids between twoPeromyscusspecies, its over-expression cannot account for the aberrant phenotypes of these placentae. We argue that the species-specific imprinting ofpPl1-v, encoding a growth factor that regulates nutrient transfer from mothers to their offspring, is consistent with the parent-offspring conflict model that has been proposed to explain the evolution of genomic imprinting.