Physical and functional HAT/HDAC interplay regulates protein acetylation balance.
Physical and functional HAT/HDAC interplay regulates protein acetylation balance.
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DOI：
10.1155/2011/371832
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发表时间：
2011
影响因子：
--
通讯作者：
Simone C
中科院分区：
文献类型：
--
作者：
Peserico A;Simone C
蛋白质乙酰化和脱乙酰化之间的平衡控制着几种生理和病理细胞过程，并且参与维持这种平衡的酶-乙酰转移酶（HAT）和脱乙酰酶（HDAC）-已被广泛研究。目前，该领域的研究表明，动态乙酰化平衡主要是通过HAT和HDAC活性之间的物理和功能相互作用来维持的。该模型克服了经典的观点，即乙酰化的表观遗传标记仅具有激活功能，而去乙酰化标记具有抑制活性。考虑到存在几个参与保持这种平衡的参与者，这些相互作用蛋白质的复杂网络的鉴定可能会促进我们对细胞如何调节细胞内过程和响应细胞外环境的理解，并将为基于人类疾病的表观遗传药物的新治疗方法提供理论基础。
The balance between protein acetylation and deacetylation controls several physiological and pathological cellular processes, and the enzymes involved in the maintenance of this equilibrium—acetyltransferases (HATs) and deacetylases (HDACs)—have been widely studied. Presently, the evidences obtained in this field suggest that the dynamic acetylation equilibrium is mostly maintained through the physical and functional interplay between HAT and HDAC activities. This model overcomes the classical vision in which the epigenetic marks of acetylation have only an activating function whereas deacetylation marks have a repressing activity. Given the existence of several players involved in the preservation of this equilibrium, the identification of these complex networks of interacting proteins will likely foster our understanding of how cells regulate intracellular processes and respond to the extracellular environment and will offer the rationale for new therapeutic approaches based on epigenetic drugs in human diseases.
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作者：
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DOI：
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发表时间：
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影响因子：
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