Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology.
Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology.
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DOI：
10.1016/j.steroids.2008.11.013
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发表时间：
2009-07
期刊：
影响因子：
2.7
通讯作者：
Mermelstein, Paul G.
中科院分区：
文献类型：
--
作者：
Boulware, Marissa I.;Mermelstein, Paul G.
直到最近，雌二醇可以独立于核雌激素受体影响细胞过程的想法通常被认为是人为因素。尽管在神经系统内外进行了大量仔细控制的研究，证明雌激素通过作用于细胞膜表面和/或以与基因组启动事件的时间进程不相容的生物速率调节各种细胞内信号传导途径。雌二醇可以作用于表面膜受体以调节神经系统功能的概念现在远没有那么有争议。然而，有证据表明，细胞膜表面可能存在多种类型的雌激素受体。目前正在确定这些受体中每一种的生理相关性。事实上，两种重要的膜雌激素受体是经典的雌激素受体α（ER α）和雌激素受体β（ER β）蛋白，基于它们在核基因转录中的良好作用，这有点令人惊讶。本文综述了ER α和ER β通过激活代谢型谷氨酸受体（mGluRs）刺激神经系统细胞内信号转导的机制。雌激素受体功能的这种机制也需要小窝蛋白，其提供适当细胞刺激所需的特定信号组分的亚细胞区室化。审查将结束与ER/mGluR信号的明显调节下的生理过程的几个例子。
Until recently, the idea that estradiol could affect cellular processes independent of nuclear estrogen receptors was often dismissed as artifact. This in spite of a large number of carefully controlled studies performed both within and outside the nervous system demonstrating estrogens regulate various intracellular signaling pathways by acting at the membrane surface of cells and/or at biological rates incompatible with the time course of genomic-initiated events. The concept that estradiol can act on surface membrane receptors to regulate nervous system function is now far less controversial. However, there is evidence that there may be multiple types of estrogen receptors on the membrane surface of cells. Determining the physiological relevance of each of these receptors is currently underway. Two important membrane estrogen receptors are in fact the classical estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) proteins, which is somewhat surprising based upon their well-established role in nuclear gene transcription. This review will focus on the mechanism by which surface-localized ERα and ERβ stimulate intracellular signaling events in cells of the nervous system through activation of metabotropic glutamate receptors (mGluRs). This mechanism of estrogen receptor function also requires caveolin proteins, which provide the subcellular compartmentalization of the particular signaling components required for appropriate cell stimulation. The review will conclude with several examples of physiological processes under the apparent regulation of ER/mGluR signaling.
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DOI：
10.1073/pnas.91.18.8517
发表时间：
1994-08-30
影响因子：
11.1
作者：
ARONICA, SM;KRAUS, WL;KATZENELLENBOGEN, BS
通讯作者：
KATZENELLENBOGEN, BS
影响因子：
5.3
作者：
Dewing, Phoebe;Boulware, Marissa I.;Micevych, Paul
通讯作者：
Micevych, Paul
影响因子：
4.8
作者：
Kahlert, S;Nuedling, S;Grohé, C
通讯作者：
Grohé, C
影响因子：
5.3
作者：
Boulware, Marissa I.;Kordasiewicz, Holly;Mermelstein, Paul G.
通讯作者：
Mermelstein, Paul G.
影响因子：
3.6
作者：
BECKER, JB;SNYDER, PJ;JENUWINE, MJ
通讯作者：
JENUWINE, MJ