Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study
Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study
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DOI：
10.1016/j.ajo.2016.12.015
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发表时间：
2017-03-01
影响因子：
4.2
通讯作者：
Wisse, Robert P. L.
中科院分区：
文献类型：
--
作者：
Godefrooij, Daniel A.;De Wit, G. Ardine;Wisse, Robert P. L.
目的：确定现代诊断时代圆锥角膜的年龄别发病率和患病率。设计：流行病学研究。部分：从强制性医疗保险数据库中收集440万名患者。方法：数据摘自荷兰最大的医疗保险提供商。将10~40岁的患者定义为新诊断圆锥角膜的相应年龄段，并确定新诊断圆锥角膜的年发病率。圆锥角膜的患病率是根据年发病率、确诊时的平均年龄和平均预期寿命来估计的。结果：圆锥角膜年发病率为1：7500(13.3/10万，95%可信区间：11.6~15.2)，一般人群圆锥角膜患病率为1：375(265/10万，95%可信区间：260~270)。这些数值比以前在人口研究中报告的数值高出5到10倍。确诊时的平均年龄为28.3岁，60.6%的确诊患者为男性。结论：圆锥角膜的年发病率和患病率都比之前报道的高出5倍到10倍。(C)2016爱思唯尔公司。保留所有权利。
PURPOSE: To determine the age-specific incidence and prevalence of keratoconus in the modern era of diagnostics.DESIGN: Epidemiologic study.PARTICIPANTS: Total of 4.4 million patients from a mandatory health insurance database.METHODS: Data were extracted from the largest health insurance provider in the Netherlands. Patients aged 10-40 years were defined as the relevant age category for newly diagnosed keratoconus and the annual incidence of newly diagnosed keratoconus was determined. The prevalence of keratoconus was estimated based on the annual incidence, mean age at diagnosis, and average life expectancy. Main outcome measure was the annual incidence and prevalence of keratoconus.RESULTS: The annual incidence of keratoconus was 1:7500 in the relevant age category (13.3 cases per 100 000, 95% confidence interval [CI]: 11.6-15.2) and the estimated prevalence of keratoconus in the general population was 1:375 (265 cases per 100 000, 95% CI: 260-270). These values are 5-fold to 10-fold higher than previously reported values in population studies. The mean age at diagnosis was 28.3 years and 60.6% of diagnosed patients were male. "CONCLUSIONS: Both the annual incidence and the prevalence of keratoconus were 5-fold to 10-fold higher than previously reported. (C) 2016 Elsevier Inc. All rights reserved.