Doxorubicin cardiotoxicity and target cells: a broader perspective.
Doxorubicin cardiotoxicity and target cells: a broader perspective.
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DOI：
10.1186/s40959-016-0012-4
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发表时间：
2016-03-03
期刊：
影响因子：
--
通讯作者：
Berrino L
中科院分区：
文献类型：
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作者：
De Angelis A;Urbanek K;Cappetta D;Piegari E;Ciuffreda LP;Rivellino A;Russo R;Esposito G;Rossi F;Berrino L
随着癌症幸存者人数的增加，阿霉素的心脏毒性正成为一个跨学科的研究热点。这种并发症的复杂和不完全理解的发病机制使得难以设计成功的预防或治疗措施。虽然心肌细胞被认为是经典的细胞靶点，但其他细胞包括各种类型的未分化细胞也参与心肌稳态。这种观点可能揭示了以前未被认识到的心脏毒性方面，并促进新的实验和临床心脏保护策略。在这篇综述中，多柔比星的不同细胞靶点进行了讨论，重点是心脏祖细胞，氧化应激，DNA损伤，衰老和凋亡，所有这些都有助于其受损的功能特性。
The cardiotoxicity of doxorubicin is becoming an interdisciplinary point of interest given a growing population of cancer survivors. The complex and not completely understood pathogenesis of this complication makes difficult to design successful preventive or curative measures. Although cardiomyocyte has been considered a classical cellular target, other cells including various types of undifferentiated cells are involved in myocardial homeostasis. Such perspective may shed light on previously unrecognized aspects of cardiotoxicity and promote new experimental and clinical cardioprotective strategies. In this review, different cellular targets of doxorubicin are discussed with the focus on cardiac progenitor cells, oxidative stress, DNA damage, senescence and apoptosis all of which contribute to their compromised functional properties.