The Role of Sleep and Sleep Disorders in the Development, Diagnosis, and Management of Neurocognitive Disorders.
The Role of Sleep and Sleep Disorders in the Development, Diagnosis, and Management of Neurocognitive Disorders.
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DOI：
10.3389/fneur.2015.00224
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发表时间：
2015
影响因子：
3.4
通讯作者：
Miller MA
中科院分区：
文献类型：
--
作者：
Miller MA
越来越明显的是，睡眠在维护，疾病预防，修复和恢复身心方面发挥着重要作用。睡眠和觉醒周期由下丘脑中的视交叉上核的起搏活动控制，但也可能被神经系统疾病破坏，导致睡眠障碍。睡眠不足与全因死亡率的增加有关。同样，睡眠障碍和睡眠障碍可能会破坏神经通路，并对神经系统疾病产生影响。对正常受试者的睡眠剥夺研究表明，睡眠不足会导致注意力和工作记忆受损。此外，未经治疗的睡眠障碍和睡眠障碍，如阻塞性睡眠呼吸暂停（OSA），也可能导致认知障碍。睡眠不足和睡眠障碍可能是痴呆症发展的重要风险因素。在这篇综述中，睡眠和睡眠障碍在神经认知障碍[痴呆和轻度认知障碍（MCI）]发展中的潜在机制和作用，以及睡眠障碍的存在如何指导神经认知障碍的诊断和管理过程将被讨论。
It is becoming increasingly apparent that sleep plays an important role in the maintenance, disease prevention, repair, and restoration of both mind and body. The sleep and wake cycles are controlled by the pacemaker activity of the superchiasmic nucleus in the hypothalamus but can be disrupted by diseases of the nervous system causing disordered sleep. A lack of sleep has been associated with an increase in all-cause mortality. Likewise, sleep disturbances and sleep disorders may disrupt neuronal pathways and have an impact on neurological diseases. Sleep deprivation studies in normal subjects demonstrate that a lack of sleep can cause attention and working memory impairment. Moreover, untreated sleep disturbances and sleep disorders such as obstructive sleep apnoe (OSA) can also lead to cognitive impairment. Poor sleep and sleep disorders may present a significant risk factor for the development of dementia. In this review, the underlying mechanisms and the role of sleep and sleep disorders in the development of neurocognitive disorders [dementia and mild cognitive impairment (MCI)] and how the presence of sleep disorders could direct the process of diagnosis and management of neurocognitive disorders will be discussed.