Telomere Length Maintenance, Shortening, and Lengthening
Telomere Length Maintenance, Shortening, and Lengthening
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DOI：
10.1002/jcp.24537
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发表时间：
2014-10
影响因子：
5.6
通讯作者：
Zhenrong Zhao;X. Pan;Lin Liu;Na Liu
中科院分区：
文献类型：
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作者：
Zhenrong Zhao;X. Pan;Lin Liu;Na Liu
端粒维持染色体的稳定性和细胞的复制能力。端粒缩短伴随着衰老而发生。短端粒与一些疾病有关，如先天性角化不良、特发性肺纤维化和再生障碍性贫血。端粒在多能干细胞中比在体细胞中更长，并且在植入前发育期间显著延长。此外，体细胞重编程过程中的端粒延长在获得真正的多能性中非常重要。这篇综述主要集中在端粒长度维持在多能细胞，端粒长度延长在早期胚胎发育的调控机制，以及端粒再生体细胞重编程。端粒相关疾病也在此综述中进行了讨论。J.细胞。229：1323-1329，2014。© 2014 Wiley Periodicals，Inc.
Telomeres maintain chromosome stability and cell replicative capacity. Telomere shortening occurs concomitant with aging. Short telomeres are associated with some diseases, such as dyskeratosis congenita, idiopathic pulmonary fibrosis, and aplastic anemia. Telomeres are longer in pluripotent stem cells than in somatic cells and lengthen significantly during preimplantation development. Furthermore, telomere elongation during somatic cell reprogramming is of great importance in the acquisition of authentic pluripotency. This review focuses primarily on regulatory mechanisms of telomere length maintenance in pluripotent cells, telomere length extension in early embryo development, and also telomere rejuvenation in somatic cell reprogramming. Telomere related diseases are also discussed in this review. J. Cell. Physiol. 229: 1323–1329, 2014. © 2014 Wiley Periodicals, Inc.