The spectrum of cutaneous lymphomas in Japan: a study of 62 cases based on the World Health Organization Classification
The spectrum of cutaneous lymphomas in Japan: a study of 62 cases based on the World Health Organization Classification
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DOI：
10.1111/j.1600-0560.2006.00460.x
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发表时间：
2006-07-01
影响因子：
1.7
通讯作者：
Hata, Hiroo
中科院分区：
文献类型：
--
作者：
Yasukawa, Kana;Kato, Naoko;Hata, Hiroo
背景：恶性淋巴瘤亚型的相对发病率因地理位置的不同而不同。本研究调查了日本皮肤淋巴瘤亚型的流行病学，并与其他国家进行了比较。方法：回顾性分析北海道癌症中心皮肤科62例皮肤淋巴瘤患者的临床资料。采用世界卫生组织对造血和淋巴系统恶性肿瘤的分类。结果：62例患者中原发性皮肤淋巴瘤（PCL） 31例，继发性皮肤淋巴瘤（SCL） 31例。T和NK细胞淋巴瘤占PCL的80%，其中蕈样真菌病约占35%。31例继发性皮肤淋巴瘤患者中，17例（54%）为T细胞和nk细胞淋巴瘤，其中9例为成人T细胞白血病/淋巴瘤，14例（46%）为b细胞淋巴瘤，其中11例为弥漫性大b细胞淋巴瘤。大多数伴有原发性或继发性皮肤病变的SCL和nk细胞淋巴瘤患者预后较差。结论：本研究PCL发病率与日本其他机构相似，但发病率与其他国家不同，提示不同PCL亚型的相对发病率因地理位置的不同而不同，类似于以往报道的系统性恶性淋巴瘤。
Background:The relative incidence of malignant lymphoma subtypes differs according to geographic location. This study investigated the epidemiology of cutaneous lymphoma subtypes in Japan and compared it with other countries.Methods:Sixty-two patients with cutaneous lymphoma attending the Department of Dermatology, National Hospital Organization Hokkaido Cancer Center were reviewed. The World Health Organization classification of hematopoietic and lymphoid malignancies was adopted.Results:Of the 62 patients, 31 had primary cutaneous lymphoma (PCL) and 31 had secondary cutaneous lymphoma (SCL). T- and natural killer (NK)-cell lymphoma accounted for 80% of PCL, of which, mycosis fungoides accounted for almost 35%. Of the 31 patients with secondary cutaneous lymphoma, 17 patients (54%) had T- and NK-cell lymphoma, including nine adult T-cell leukemia/lymphoma patients, and 14 patients (46%) had B-cell lymphoma, including 11 diffuse large B-cell lymphoma patients. The majority of patients with SCL and NK-cell lymphoma with primary or secondary skin lesions had a poor outcome.Conclusions:PCL in this study showed a similar incidence to that of other institutions in Japan, while also demonstrating different frequencies from that of other countries, suggesting that the relative frequency of different PCL subtypes differ according to geographical location, similar to previous reports of systemic malignant lymphoma.