53BP1-mediated DNA double strand break repair: Insert bad pun here
53BP1-mediated DNA double strand break repair: Insert bad pun here
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DOI：
10.1016/j.dnarep.2011.07.012
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发表时间：
2011-10-10
期刊：
影响因子：
3.8
通讯作者：
Goodarzi, Aaron A.
中科院分区：
文献类型：
--
作者：
Noon, Angela T.;Goodarzi, Aaron A.
53 BP 1是对DNA损伤的细胞反应中的既定参与者，并且是电离辐射诱导的病灶的典型组分-辐射暴露后在DNA双链断裂处组装的蛋白质骨干，并且其易于通过免疫荧光显微镜观察。虽然它在p53调控和细胞周期检查点激活中的作用已经研究了一段时间，但53 BP 1对DNA双链断裂重新连接的影响只是在过去几年才被发现。令人信服的证据，现在存在的5313 P1显着影响DNA双链断裂修复的结果在几种情况下，其中许多暗示了一个重要的作用，在调节周围的断裂位点的染色质结构。在这里，我们强调了已知的和新出现的作用，53 BP 1在DNA双链断裂修复，包括修复损伤诱导异染色质内，端粒脱帽后，在长距离V（D）1重组，在免疫球蛋白类转换重组和其备受争议的作用，在同源重组过程中调节切除。(C)2011 Elsevier B. V.保留所有权利。
53BP1 is an established player in the cellular response to DNA damage and is a canonical component of ionizing-radiation induced foci - that cadre of proteins which assemble at DNA double strand breaks following radiation exposure and which are readily visualized by immunofluorescence microscopy. While its roles in p53 regulation and cell cycle checkpoint activation have been studied for some time, the impact of 53BP1 on DNA double strand break rejoining has only come to light in the past few years. Convincing evidence now exists for 5313P1 significantly affecting the outcome of DNA double strand break repair in several contexts, many of which hint to an important role in modulating chromatin structure surrounding the break site. Here, we highlight the known and emerging roles of 53BP1 in DNA double strand break repair, including the repair of lesions induced within heterochromatin, following telomere uncapping, in long-range V(D)1 recombination, during immunoglobulin class switch recombination and its much debated role in regulating resection during homologous recombination. (C) 2011 Elsevier B.V. All rights reserved.