Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
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DOI:
10.1186/gb-2009-10-3-r25
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发表时间:
2009
期刊:
影响因子:
12.3
通讯作者:
Salzberg SL
中科院分区:
文献类型:
--
作者:
Langmead B;Trapnell C;Pop M;Salzberg SL
Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes. Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches. Multiple processor cores can be used simultaneously to achieve even greater alignment speeds. Bowtie is open source .
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