Endometrioid adenocarcinoma with a functioning stroma
Endometrioid adenocarcinoma with a functioning stroma
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DOI：
10.1111/j.1447-0756.2007.00541.x
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发表时间：
2007-06-01
影响因子：
1.6
通讯作者：
Kurachi, Hirohisa
中科院分区：
文献类型：
--
作者：
Hayasaka, Tadashi;Nakahara, Kenji;Kurachi, Hirohisa
一个70岁的妇女与功能性间质卵巢类腺癌的情况下提出。症状为绝经后出血。术前血清雌二醇水平高达162.4 pg/mL，血清促性腺激素水平受到抑制。子宫内膜组织呈增生性改变。手术标本包括一个直径95 mm的多房性囊性卵巢肿瘤和一个增大的子宫。组织学上，肿瘤由增殖的、非典型的、柱状的癌细胞组成，类似于早期分泌的子宫内膜细胞，和浓缩的羽毛状基质细胞类似于卵泡膜黄体细胞。诊断为卵巢子宫内膜腺癌伴功能性间质。手术后，血清雌二醇水平下降，卵泡刺激素水平升高。几乎所有类型的卵巢肿瘤都被报道与内分泌异常有关。卵巢粘液性上皮性肿瘤最常出现雌激素性间质，尽管卵巢样腺癌出现功能性间质的频率很低。在这里，一个罕见的情况下，病人的临床过程和组织病理学结果的报告。
A case of a 70-year-old woman with endometrioid adenocarcinoma of the ovary with functioning stroma is presented. The symptom was postmenopausal bleeding. The preoperative level of serum estradiol was as high as 162.4 pg/mL, and serum gonadotropin levels were suppressed. The endometrial tissue showed hyperplastic changes. The surgical specimens consisted of a multilocular cystic ovarian tumor of 95 mm in diameter and an enlarged uterus. Histologically, the tumor was composed of proliferating, atypical, columnar cancer cells resembling early secretory endometrial cells, and condensation of plumed stromal cells resembling theca lutein cells. The diagnosis of endometrial adenocarcinoma of the ovary with functioning stroma was made. After surgery, the serum levels of estradiol decreased and of follicle-stimulating hormone increased. Almost all types of ovarian tumor have been reported to be associated with endocrine abnormalities. Mucinous epithelial ovarian tumors most commonly present with estrogenic stroma, although the frequency of endometrioid adenocarcinoma with functioning stroma is very low. Here, a rare case with the patient's clinical course and histopathologic findings is reported.