Cholecystokinin.
Cholecystokinin.
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DOI：
10.1097/med.0b013e3280122850
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发表时间：
2007-02-01
期刊：
影响因子：
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通讯作者：
Liddle, Rodger A
中科院分区：
文献类型：
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作者：
Chandra, Rashmi;Liddle, Rodger A
综述的目的：激素胆囊收缩素是在1928年发现的，因为它能够诱导胆囊收缩。从那时起，胆囊收缩素已被证明在胃肠道和大脑中具有多种功能。这篇综述讨论了胆囊收缩素生物学的几个重要进展，显示它如何在胃肠道疾病中发挥作用，包括控制食欲。最近的发现：胆囊收缩素被证明是通过CCK-1受体相互作用，位于专门的区域，后脑引起饱腹感。胆囊收缩素还抑制下丘脑中的食欲肽的表达，并防止生长激素释放肽对特化神经元的刺激。在胰腺中，胆囊收缩素增加了产生胰岛素的β细胞的增殖，并减少了胰岛素诱导的摄食过多。胆囊收缩素水平升高降低食欲和减少肠道炎症引起的寄生虫和细菌toxin.SUMMARY：了解胆囊收缩素调节食欲途径在体内的机制可能会导致控制食欲相关的疾病，如肥胖和贪食症的策略。饮食脂肪（通过升高胆囊收缩素）减少肠道炎症表明，该激素在调节食物的摄入和消化中起着综合作用，这可能与胃肠道炎性疾病有关。
PURPOSE OF REVIEW: The hormone cholecystokinin was discovered in 1928 because of its ability to induce gallbladder contraction. Since then, cholecystokinin has been shown to possess multiple functions in the gastrointestinal tract and brain. This review discusses several significant developments in cholecystokinin biology that show how it plays a role in gastrointestinal diseases, including control of appetite.RECENT FINDINGS: Cholecystokinin was shown to induce satiety by interacting through CCK-1 receptors located in specialized regions of the hindbrain. Cholecystokinin also inhibits expression of orexigenic peptides in the hypothalamus and prevents stimulation of specialized neurons by ghrelin. In the pancreas, cholecystokinin increased the proliferation of insulin-producing beta cells and reduced insulin-induced hyperphagia. Elevated cholecystokinin levels decreased appetite and reduced intestinal inflammation caused by parasites and bacterial toxins.SUMMARY: Understanding the mechanisms by which cholecystokinin regulates orexigenic pathways in the body may lead to strategies for controlling appetite-related disorders such as obesity and bulimia. The reduction of intestinal inflammation by dietary fats (by elevating cholecystokinin) suggests that the hormone plays an integrated role in regulating the ingestion and digestion of food that may be relevant to inflammatory diseases of the gastrointestinal tract.